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Identification of CCR9- murine plasmacytoid DC precursors with plasticity to differentiate into conventional DCs.
Blood 117, 6562-6570 (2011)
Whereas the final differentiation of conventional dendritic cells (CDCs) from committed precursors occurs locally in secondary lymphoid or peripheral tissues, plasmacytoid dendritic cells (PDCs) are thought to fully develop in the bone marrow from common DC progenitors before migrating to the periphery. In our study, we define, for the first time, a subpopulation of CCR9(-) major histocompatibility complex class II(low) PDCs in murine bone marrow, which express E2-2 and are immediate precursors of CCR9(+) fully differentiated PDCs. However, CCR9(-) PDCs have the plasticity to acquire the phenotype and function of CD11b(+) CD8α(-) major histocompatibility complex class II(high) CDC-like cells under the influence of soluble factors produced by intestinal epithelial cells or recombinant GM-CSF. This deviation from the PDC lineage commitment is regulated on the level of transcription factors reflected by down-regulation of E2-2 and up-regulation of ID2, PU.1, and BATF3. Thus, CCR9(-) PDCs are immediate PDC precursors that can be reprogrammed to differentiate into CDC-like cells with higher antigen-presenting and cytokine-producing capacity under the influence of the local tissue microenvironment.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Dendritic cell-development; Interferon-producing cells; Bone-marrow; In-vivo; Virus-infection; Mouse; CD8-ALPHA(+); Transcription; Autoimmunity; Homeostasis
Language
english
Publication Year
2011
HGF-reported in Year
2011
ISSN (print) / ISBN
0006-4971
e-ISSN
1528-0020
Journal
Blood
Quellenangaben
Volume: 117,
Issue: 24,
Pages: 6562-6570
Publisher
American Society of Hematology
Reviewing status
Peer reviewed
Institute(s)
Institute of Virology (VIRO)
POF-Topic(s)
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s)
Immune Response and Infection
PSP Element(s)
G-520100-001
PubMed ID
21508410
Erfassungsdatum
2011-07-20