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Domenighetti, C.* ; Sugier, P.E.* ; Ashok Kumar Sreelatha, A.* ; Schulte, C.* ; Grover, S.* ; Mohamed, O.* ; Portugal, B.* ; May, P.* ; Bobbili, D.R.* ; Radivojkov-Blagojevic, M. ; Lichtner, P. ; Singleton, A.B.* ; Hernandez, D.G.* ; Edsall, C.* ; Mellick, G.D.* ; Zimprich, A.* ; Pirker, W.* ; Rogaeva, E.* ; Lang, A.E.* ; Kõks, S.* ; Taba, P.* ; Lesage, S.* ; Brice, A.* ; Corvol, J.C.* ; Chartier-Harlin, M.C.* ; Mutez, E.* ; Brockmann, K.* ; Deutschländer, A.B.* ; Hadjigeorgiou, G.M.* ; Dardiotis, E.* ; Stefanis, L.* ; Simitsi, A.M.* ; Valente, E.M.* ; Petrucci, S.* ; Duga, S.* ; Straniero, L.* ; Zecchinelli, A.* ; Pezzoli, G.* ; Brighina, L.* ; Ferrarese, C.* ; Annesi, G.* ; Quattrone, A.* ; Gagliardi, M.* ; Matsuo, H.* ; Kawamura, Y.* ; Hattori, N.* ; Nishioka, K.* ; Chung, S.J.* ; Kim, Y.J.* ; Kolber, P.* ; van de Warrenburg, B.P.C.* ; Bloem, B.R.* ; Aasly, J.O.* ; Toft, M.F.* ; Pihlstrøm, L.* ; Correia Guedes, L.* ; Ferreira, J.J.* ; Bardien, S.* ; Carr, J.* ; Tolosa, E.* ; Ezquerra, M.* ; Pastor, P.* ; Diez-Fairen, M.* ; Wirdefeldt, K.* ; Pedersen, N.L.* ; Ran, C.* ; Belin, A.C.* ; Puschmann, A.J.* ; Hellberg, C.* ; Clarke, C.E.* ; Morrison, K.E.* ; Tan, M.* ; Krainc, D.* ; Burbulla, L.F.* ; Farrer, M.J.* ; Krüger, R.* ; Gasser, T.* ; Sharma, M.* ; Elbaz, A.*

Dairy intake and Parkinson's disease: A mendelian randomization study.

Mov. Disord. 37, 857-864 (2022)
Research data DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
BACKGROUND: Previous prospective studies highlighted dairy intake as a risk factor for Parkinson's disease (PD), particularly in men. It is unclear whether this association is causal or explained by reverse causation or confounding. OBJECTIVE: The aim is to examine the association between genetically predicted dairy intake and PD using two-sample Mendelian randomization (MR). METHODS: We genotyped a well-established instrumental variable for dairy intake located in the lactase gene (rs4988235) within the Courage-PD consortium (23 studies; 9823 patients and 8376 controls of European ancestry). RESULTS: Based on a dominant model, there was an association between genetic predisposition toward higher dairy intake and PD (odds ratio [OR] per one serving per day = 1.70, 95% confidence interval = 1.12-2.60, P = 0.013) that was restricted to men (OR = 2.50 [1.37-4.56], P = 0.003; P-difference with women = 0.029). CONCLUSIONS: Using MR, our findings provide further support for a causal relationship between dairy intake and higher PD risk, not biased by confounding or reverse causation. Further studies are needed to elucidate the underlying mechanisms. © 2022 International Parkinson and Movement Disorder Society.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Dairy Intake; Parkinson's Disease; Mendelian Randomization; Ischemic-heart-disease; Milk Consumption; Risk; Metaanalysis; Association; Genotype
Language english
Publication Year 2022
HGF-reported in Year 2022
ISSN (print) / ISBN 0885-3185
e-ISSN 1531-8257
Journal Movement Disorders
Quellenangaben Volume: 37, Issue: 4, Pages: 857-864 Article Number: , Supplement: ,
Publisher Wiley
Publishing Place 111 River St, Hoboken 07030-5774, Nj Usa
Reviewing status Peer reviewed
Institute(s) Institute of Human Genetics (IHG)
POF-Topic(s) 30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
Research field(s) Genetics and Epidemiology
PSP Element(s) G-500700-001
Grants National Research Foundation of South Africa (NRF)
Universiteit Stellenbosch
Medical Research Council
Ministerio de Ciencia e Innovación
Michael J Fox Foundation
Karolinska Institutet
Italian Ministry of Health
German Research Council
EU Joint Program for Neurodegenerative Disease research
Eesti Teadusagentuur
MSA Coalition
Multiple Sclerosis Society of Western Australia
Université Paris-Saclay
UK Medical Research Council
Swedish Research Council
South African Medical Research Council
Parkinson's UK
NIH HHS
Consortium canadien en neurodégénérescence associée au vieillissement
DOI 10.1002/mds.28902
WOS ID WOS:000740333300001
PubMed ID 34997937
Erfassungsdatum 2022-02-08
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