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Applications and immunological effects of quantum dots on respiratory system.
Front. Immunol. 12:795232 (2022)
Quantum dots (QDs), are one kind of nanoscale semiconductor crystals with specific electronic and optical properties, offering near-infrared mission and chemically active surfaces. Increasing interest for QDs exists in developing theranostics platforms for bioapplications such as imaging, drug delivery and therapy. Here we summarized QDs' biomedical applications, toxicity, and immunological effects on the respiratory system. Bioapplications of QDs in lung include biomedical imaging, drug delivery, bio-sensing or diagnosis and therapy. Generically, toxic effects of nanoparticles are related to the generation of oxidative stresses with subsequent DNA damage and decreased lung cells viability in vitro and in vivo because of release of toxic metal ions or the features of QDs like its surface charge. Lastly, pulmonary immunological effects of QDs mainly include proinflammatory cytokines release and recruiting innate leukocytes or adaptive T cells.
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Publication type
Article: Journal article
Document type
Review
Keywords
Quantum Dot ; Respiratory System ; Biomedical Applications ; Cytotoxicity ; Immunological Effects; Bronchial Epithelial-cells; Surface-chemistry; Lung Cancers; Inflammation; Expression; Biodistribution; Toxicity; Nanoparticles; Cytotoxicity; Pathways
ISSN (print) / ISBN
1664-3224
e-ISSN
1664-3224
Journal
Frontiers in Immunology
Quellenangaben
Volume: 12,
Article Number: 795232
Publisher
Frontiers
Publishing Place
Avenue Du Tribunal Federal 34, Lausanne, Ch-1015, Switzerland
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Lung Health and Immunity (LHI)
Grants
Clinical research of Health and Family Planning Commission of Shenzhen Municipality
National Natural Science Foundation of China
National Natural Science Foundation of China