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Friedland, W. ; Dingfelder, M.* ; Kundrát, P. ; Jacob, P.

Track structures, DNA targets and radiation effects in the biophysical Monte Carlo simulation code PARTRAC.

Mutat. Res. -Fund. Mol. Mech. Mutag. 711, 28-40 (2011)

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Open Access Green as soon as Postprint is submitted to ZB.

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This review describes the PARTRAC suite of comprehensive Monte Carlo simulation tools for calculations of track structures of a variety of ionizing radiation qualities and their biological effects. A multi-scale target model characterizes essential structures of the whole genomic DNA within human fibroblasts and lymphocytes in atomic resolution. Calculation methods and essential results are recapitulated regarding the physical, physico-chemical and chemical stage of track structure development of radiation damage induction. Recent model extension towards DNA repair processes extends the time dimension by about 12 orders of magnitude and paves the way for superior predictions of radiation risks.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Modelling; Track structure; Multi-scale; DNA damage; DNA repair

ISSN (print) / ISBN 0027-5107

e-ISSN 1873-135X

Journal Mutation Research / Fundamental and Molecular Mechanisms of Mutagenesis

Quellenangaben Volume: 711, Issue: 1-2, Pages: 28-40

Publisher Elsevier

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Radiation Protection (ISS)