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Mejhert, N.* ; Gabriel, K.R.* ; Frendo-Cumbo, S.* ; Krahmer, N. ; Song, J.* ; Kuruvilla, L.* ; Chitraju, C.* ; Boland, S.* ; Jang, D.K.* ; von Grotthuss, M.* ; Costanzo, M.C.* ; Rydén, M.* ; Olzmann, J.A.* ; Flannick, J.* ; Burtt, N.P.* ; Farese, R.V.*

The Lipid Droplet Knowledge Portal: A resource for systematic analyses of lipid droplet biology.

Dev. Cell 57, 387-397.e4 (2022)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Lipid droplets (LDs) are organelles of cellular lipid storage with fundamental roles in energy metabolism and cell membrane homeostasis. There has been an explosion of research into the biology of LDs, in part due to their relevance in diseases of lipid storage, such as atherosclerosis, obesity, type 2 diabetes, and hepatic steatosis. Consequently, there is an increasing need for a resource that combines datasets from systematic analyses of LD biology. Here, we integrate high-confidence, systematically generated human, mouse, and fly data from studies on LDs in the framework of an online platform named the “Lipid Droplet Knowledge Portal” (https://lipiddroplet.org/). This scalable and interactive portal includes comprehensive datasets, across a variety of cell types, for LD biology, including transcriptional profiles of induced lipid storage, organellar proteomics, genome-wide screen phenotypes, and ties to human genetics. This resource is a powerful platform that can be utilized to identify determinants of lipid storage.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords C16orf54 ; Inflammation ; Msrb3 ; Proteasome ; Protein Targeting ; Proximity Labeling ; Sterol Ester ; Triacylglycerol; Low-density-lipoprotein; Cholesterol; Gene; Acyltransferase; Expression; Proteomics; Childhood; Disease; Seipin
ISSN (print) / ISBN 1534-5807
e-ISSN 1878-1551
Journal Developmental Cell
Quellenangaben Volume: 57, Issue: 3, Pages: 387-397.e4 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place 50 Hampshire St, Floor 5, Cambridge, Ma 02139 Usa
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Obesity (IDO)
Grants Aramont Fund for Emerging Science Research
NIH
Margareta af Ugglas Foundation
Knut & Alice Wallenberg Foundation
Swedish Research Council
ERC-SyG SPHERES
Novo Nordisk Foundation
Tripartite Immuno-metabolism Consortium
MSAM Consortium
MeRIAD Consortium
CIMED
Swedish Diabetes Foundation
Strategic Research Program in Diabetes at Karolinska Institutet
American Heart Association Predoctoral Fellowship
Howard Hughes Medical Institute