PuSH - Publication Server of Helmholtz Zentrum München: Prdm6 controls heart development by regulating neural crest cell differentiation and migration.

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Hong, L.* ; Li, N.* ; Gasque, V.* ; Mehta, S.* ; Ye, L.* ; Wu, Y.* ; Li, J.* ; Gewies, A. ; Ruland, J.* ; Hirschi, K.K.* ; Eichmann, A.* ; Hendry, C.* ; van Dijk, D.* ; Mani, A.*

Prdm6 controls heart development by regulating neural crest cell differentiation and migration.

JCI insight 7:e156046 (2022)

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The molecular mechanisms that drive the acquisition of distinct neural crest cell (NCC) fates is still poorly understood. Here, we identify Prdm6 as an epigenetic modifier that temporally and spatially regulates the expression of NCC specifiers and determines the fate of a subset of migrating Cardiac NCCs (CNCCs). Using transcriptomic analysis, genetic and fate mapping approaches in transgenic mice, we show that disruption of Prdm6 is associated with impaired CNCC differentiation, delamination, and migration, and leads to patent ductus arteriosus (DA)and ventricular noncompaction. Bulk and single-cell RNA-seq analyses of DA and CNCC identify Prdm6 as a regulator of a network of CNCC specification genes including Wnt1, Tfap2b, and Sox9. Loss of Prdm6 in CNCCs diminishes its expression in pre-EMT cluster, resulting in the retention of NCC in the dorsal neural tube. This defect is associated with diminished H4K20 mono-methylation and G1-S progression and augmented Wnt1 transcript levels in pre-EMT and neural tube clusters, which we show is the major driver of the impaired CNCC migration. Altogether, these findings reveal Prdm6 as a key regulator of CNCC differentiation and migration and identify Prdm6 and its regulated network as potential targets for the treatment of congenital heart diseases.

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