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Luecken, M. ; Zaragosi, L.E.* ; Madissoon, E.* ; Sikkema, L. ; Firsova, A.B.* ; De Domenico, E.* ; Kuemmerle, L. ; Saglam, A.* ; Berg, M.* ; Gay, A.C.A.* ; Schniering, J. ; Mayr, C. ; Abalo, X.M.* ; Larsson, L.* ; Sountoulidis, A.* ; Teichmann, S.* ; van Eunen, K.* ; Koppelman, G.H.* ; Saeb-Parsy, K.* ; Leroy, S.* ; Powell, P.* ; Sarkans, U.* ; Timens, W.* ; Lundeberg, J.* ; van den Berge, M.* ; Nilsson, M.* ; Horváth, P.* ; Denning, J.* ; Papatheodorou, I.* ; Schultze, J.L.* ; Schiller, H. B. ; Barbry, P.* ; Petoukhov, I.* ; Misharin, A.V.* ; Adcock, I.* ; von Papen, M.* ; Theis, F.J. ; Samakovlis, C.* ; Meyer, K.B.* ; Nawijn, M.C.*

The discovAIR project: A roadmap towards the Human Lung Cell Atlas.

Eur. Respir. J. 59:2102057 (2022)
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The Human Cell Atlas (HCA) consortium aims to establish an atlas of all organs in the healthy human body at single-cell resolution to increase our understanding of basic biological processes that govern development, physiology and anatomy, and to accelerate diagnosis and treatment of disease. The lung biological network of the HCA aims to generate the Human Lung Cell Atlas as a reference for the cellular repertoire, molecular cell states and phenotypes, and the cell-cell interactions that characterise normal lung homeostasis in healthy lung tissue. Such a reference atlas of the healthy human lung will facilitate mapping the changes in the cellular landscape in disease. The discovAIR project is one of six pilot actions for the HCA funded by the European Commission in the context of the H2020 framework program. DiscovAIR aims to establish the first draft of an integrated Human Lung Cell Atlas, combining single-cell transcriptional and epigenetic profiling with spatially resolving techniques on matched tissue samples, as well as including a number of chronic and infectious diseases of the lung. The integrated Lung Cell Atlas will be available as a resource for the wider respiratory community, including basic and translational scientists, clinical medicine, and the private sector, as well as for patients with lung disease and the interested lay public. We anticipate that the Lung Cell Atlas will be the founding stone for a more detailed understanding of the pathogenesis of lung diseases, guiding the design of novel diagnostics and preventive or curative interventions.
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Publication type Article: Journal article
Document type Review
Language english
Publication Year 2022
HGF-reported in Year 2022
ISSN (print) / ISBN 0903-1936
e-ISSN 1399-3003
Journal European Respiratory Journal
Quellenangaben Volume: 59, Issue: 3, Pages: , Article Number: 2102057 Supplement: ,
Publisher European Respiratory Society
Publishing Place Sheffield
Reviewing status Peer reviewed
Institute(s) German Center for Lung Research (DZL)
Institute of Lung Health and Immunity (LHI)
Institute of Computational Biology (ICB)
POF-Topic(s) 80000 - German Center for Lung Research
30202 - Environmental Health
30205 - Bioengineering and Digital Health
Research field(s) Lung Research
Enabling and Novel Technologies
PSP Element(s) G-501800-810
G-501693-001
G-503800-001
Grants European Commission (EC)/Horizon 2020 Program (HEPCAR)
DOI 10.1183/13993003.02057-2021
WOS ID WOS:000886648200004
PubMed ID 35086829
Erfassungsdatum 2022-02-09
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