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Karlina, R. ; Flexeder, C. ; Musiol, S. ; Bhattacharyya, M.* ; Schneider, E. ; Altun, I. ; Gschwendtner, S. ; Neumann, A.U. ; Nano, J. ; Schloter, M. ; Peters, A. ; Schulz, H. ; Schulz, H. ; Schmidt-Weber, C.B. ; Standl, M. ; Traidl-Hoffmann, C. ; Alessandrini, F. ; Ussar, S.

Differential effects of lung inflammation on insulin resistance in humans and mice.

Allergy 77, 2482-2497 (2022)
Publ. Version/Full Text Research data DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
BACKGROUND: The rates of obesity, its associated diseases, and allergies are raising at alarming rates in most countries. House dust mites (HDM) are highly allergenic and exposure often associates with an urban sedentary indoor lifestyle, also resulting in obesity. The aim of this study was to investigate the epidemiological association and physiological impact of lung inflammation on obesity and glucose homeostasis. METHODS: Epidemiological data from 2207 adults of the population-based KORA FF4 cohort were used to test associations between asthma and rhinitis with metrics of body weight and insulin sensitivity. To obtain functional insights, C57BL/6J mice were intranasally sensitized and challenged with HDM and simultaneously fed with either low-fat or high-fat diet for 12 weeks followed by a detailed metabolic and biochemical phenotyping of the lung, liver, and adipose tissues. RESULTS: We found a direct association of asthma with insulin resistance but not body weight in humans. In mice, co-development of obesity and HDM-induced lung inflammation attenuated inflammation in lung and perigonadal fat, with little impact on body weight, but small shifts in the composition of gut microbiota. Exposure to HDM improved glucose tolerance, reduced hepatosteatosis, and increased energy expenditure and basal metabolic rate. These effects associate with increased activity of thermogenic adipose tissues independent of uncoupling protein 1. CONCLUSIONS: Asthma associates with insulin resistance in humans, but HDM challenge results in opposing effects on glucose homeostasis in mice due to increased energy expenditure, reduced adipose inflammation, and hepatosteatosis.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Allergy ; House Dust Mites ; Inflammation ; Insulin Sensitivity ; Obesity; Allergic Airway Disease; Adipose-tissue; Obesity; Database; Brown; Thermogenesis; Metabolism; Asthma; Leads
Language english
Publication Year 2022
HGF-reported in Year 2022
ISSN (print) / ISBN 0105-4538
e-ISSN 1398-9995
Journal Allergy
Quellenangaben Volume: 77, Issue: 8, Pages: 2482-2497 Article Number: , Supplement: ,
Publisher Wiley
Publishing Place 111 River St, Hoboken 07030-5774, Nj Usa
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Obesity (IDO)
Institute for Allergy Research (IAF)
Institute of Epidemiology (EPI)
Research Unit Comparative Microbiome Analysis (COMI)
Institute of Environmental Medicine (IEM)
POF-Topic(s) 30201 - Metabolic Health
30202 - Environmental Health
80000 - German Center for Lung Research
Research field(s) Helmholtz Diabetes Center
Allergy
Genetics and Epidemiology
Environmental Sciences
PSP Element(s) G-502296-001
G-505400-001
G-504090-001
G-504000-009
G-504700-002
G-503400-001
G-504000-002
G-504700-001
G-504000-010
G-501800-401
G-504000-008
Grants Bundesministerium fur Bildung und Forschung (BMBF)
Helmholtz Zentrum Munchen - German Research Center for Environmental Health
DOI 10.1111/all.15226
WOS ID WOS:000750967800001
Scopus ID 85124488520
PubMed ID 35060125
Erfassungsdatum 2022-02-09
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