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Fritsche, L. ; Heni, M. ; Eckstein, S.S. ; Hummel, J. ; Schürmann, A.* ; Häring, H.-U. ; Preissl, H. ; Birkenfeld, A.L. ; Peter, A. ; Fritsche, A. ; Wagner, R.

Incretin hypersecretion in gestational diabetes mellitus.

J. Clin. Endocrinol. Metab. 107, e2425-e2430 (2022)
Publ. Version/Full Text Postprint DOI PMC
Open Access Green
CONTEXT: Incretins are crucial stimulators of insulin secretion following food intake. Data on incretin secretion and action during pregnancy are sparse. OBJECTIVE: The aim of the study was to investigate the incretin response during an oral glucose tolerance test in pregnant women with and without gestational diabetes. DESIGN: We analyzed data from the ongoing observational PREG study (NCT04270578). SETTING: The study was conducted at the University Hospital Tübingen. PARTICIPANTS: We examined 167 women (33 with gestational diabetes mellitus (GDM)) during gestational week 27± 2.2. INTERVENTION: Subjects underwent 5-point oral glucose tolerance tests (OGTT) with a 75 g glucose load.Main outcome measures: We assessed insulin secretion and levels of total GLP-1, GIP, glicentin and glucagon during OGTT. Linear regression was used to analyze the relation of GLP-1 and glucose with insulin secretion and the association of incretin levels on birth outcome. RESULTS: Insulin secretion was significantly lower in women with GDM (p<0.001). Postload GLP-1 and GIP were ~20% higher in women with GDM (all p<0.05) independent of age, BMI and gestational age. GLP-1 increase was associated with insulin secretion only in GDM, but not in NGT. Postprandial GLP-1 levels were negatively associated with birth weight. CONCLUSIONS: The more pronounced GLP-1 increase in women with GDM could be part of a compensatory mechanism counteracting GLP-1 resistance. Higher GLP-1 levels might be protective against fetal overgrowth.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Gdm ; Glp-1 ; Incretins ; Birth Weight; Glucagon-like Peptide-1; Insulin-resistance; Women; Pregnancy; Secretion; Association; Postpartum; Predictor; Hormones; Gut
ISSN (print) / ISBN 0021-972X
e-ISSN 1945-7197
Journal Journal of Clinical Endocrinology & Metabolism, The
Quellenangaben Volume: 107, Issue: 6, Pages: e2425-e2430 Article Number: , Supplement: ,
Publisher Endocrine Society
Publishing Place Bethesda, Md.
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes Research and Metabolic Diseases (IDM)
Grants Federal Ministry of Education and Research (BMBF)