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Chen, J.* ; Rodopoulou, S.* ; Strak, M.* ; de Hoogh, K.* ; Taj, T.* ; Poulsen, A.H.* ; Andersen, Z.J.* ; Bellander, T.* ; Brandt, J.* ; Zitt, E.* ; Fecht, D.* ; Forastiere, F.* ; Gulliver, J.* ; Hertel, O.* ; Hoffmann, B.* ; Hvidtfeldt, U.A.* ; Verschuren, W.M.M.* ; Jørgensen, J.T.* ; Katsouyanni, K.* ; Ketzel, M.* ; Lager, A.* ; Leander, K.* ; Liu, S.* ; Ljungman, P.* ; Severi, G.* ; Boutron-Ruault, M.C.* ; Magnusson, P.K.E.* ; Nagel, G.* ; Pershagen, G.* ; Peters, A. ; Rizzuto, D.* ; van der Schouw, Y.T.* ; Samoli, E.* ; Sørensen, M.* ; Stafoggia, M.* ; Tjønneland, A.* ; Weinmayr, G.* ; Wolf, K. ; Brunekreef, B.* ; Raaschou-Nielsen, O.* ; Hoek, G.*

Long-term exposure to ambient air pollution and bladder cancer incidence in a pooled European cohort: The ELAPSE project.

Br. J. Cancer 126, 1499-1507 (2022)
Publ. Version/Full Text Postprint DOI PMC
Open Access Green
BACKGROUND: The evidence linking ambient air pollution to bladder cancer is limited and mixed. METHODS: We assessed the associations of bladder cancer incidence with residential exposure to fine particles (PM2.5), nitrogen dioxide (NO2), black carbon (BC), warm season ozone (O3) and eight PM2.5 elemental components (copper, iron, potassium, nickel, sulfur, silicon, vanadium, and zinc) in a pooled cohort (N = 302,493). Exposures were primarily assessed based on 2010 measurements and back-extrapolated to the baseline years. We applied Cox proportional hazard models adjusting for individual- and area-level potential confounders. RESULTS: During an average of 18.2 years follow-up, 967 bladder cancer cases occurred. We observed a positive though statistically non-significant association between PM2.5 and bladder cancer incidence. Hazard Ratios (HR) were 1.09 (95% confidence interval (CI): 0.93-1.27) per 5 µg/m3 for 2010 exposure and 1.06 (95% CI: 0.99-1.14) for baseline exposure. Effect estimates for NO2, BC and O3 were close to unity. A positive association was observed with PM2.5 zinc (HR 1.08; 95% CI: 1.00-1.16 per 10 ng/m3). CONCLUSIONS: We found suggestive evidence of an association between long-term PM2.5 mass exposure and bladder cancer, strengthening the evidence from the few previous studies. The association with zinc in PM2.5 suggests the importance of industrial emissions.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Use Regression-models; Men; Mortality; Risk; Population; Profile; Diesel; No2; Carcinogenicity; Components
ISSN (print) / ISBN 0007-0920
e-ISSN 1532-1827
Journal British Journal of Cancer BJC
Quellenangaben Volume: 126, Issue: 10, Pages: 1499-1507 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place Campus, 4 Crinan St, London, N1 9xw, England
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology II (EPI2)
Grants Health Effects Institute (HEI)