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Chromosomal radiosensitivity and acute radiation side effects after radiotherapy in tumour patients - a follow-up study.
Radiat. Oncol. 6:32 (2011)
Radiotherapists are highly interested in optimizing doses especially for patients who tend to suffer from side effects of radiotherapy (RT). It seems to be helpful to identify radiosensitive individuals before RT. Thus we examined aberrations in FISH painted chromosomes in in vitro irradiated blood samples of a group of patients suffering from breast cancer. In parallel, a follow-up of side effects in these patients was registered and compared to detected chromosome aberrations. METHODS: Blood samples (taken before radiotherapy) were irradiated in vitro with 3 Gy X-rays and analysed by FISH-painting to obtain aberration frequencies of first cycle metaphases for each patient. Aberration frequencies were analysed statistically to identify individuals with an elevated or reduced radiation response. Clinical data of patients have been recorded in parallel to gain knowledge on acute side effects of radiotherapy. RESULTS: Eight patients with a significantly elevated or reduced aberration yield were identified by use of a t-test criterion. A comparison with clinical side effects revealed that among patients with elevated aberration yields one exhibited a higher degree of acute toxicity and two patients a premature onset of skin reaction already after a cumulative dose of only 10 Gy. A significant relationship existed between translocations in vitro and the time dependent occurrence of side effects of the skin during the therapy period. CONCLUSIONS: The results suggest that translocations can be used as a test to identify individuals with a potentially elevated radiosensitivity.
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Times Cited
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2.409
0.995
14
32
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Breast-cancer patients; Peripheral-blood lyphocytes; Normal tissue-damage; Biological dosimetry; Individual radiosensitivity; Genetic predisposition; Dicentric frequencies; Ionizing-radiation; Absorbed radiation; Neck-cancer
Language
english
Publication Year
2011
HGF-reported in Year
2011
ISSN (print) / ISBN
1748-717X
e-ISSN
1748-717X
Journal
Radiation Oncology
Quellenangaben
Volume: 6,
Issue: 1,
Article Number: 32
Publisher
BioMed Central
Reviewing status
Peer reviewed
POF-Topic(s)
30203 - Molecular Targets and Therapies
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s)
Radiation Sciences
PSP Element(s)
G-501000-001
A-660200-001
A-660200-001
PubMed ID
21473753
Scopus ID
79953687976
Erfassungsdatum
2011-08-10