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Open Access Green as soon as Postprint is submitted to ZB.
Investigating air pollution and atherosclerosis in humans: Concepts and outlook.
Prog. Cardiovasc. Dis. 53, 334-343 (2011)
Although ambient particulate matter contributes to atherosclerosis in animal models, its role in atherogenesis in humans needs to be established. This article discusses concepts, study design, and choice of health outcomes to efficiently investigate the atherogenic role of ambient air pollution, with an emphasis on early preclinical biomarkers of atherosclerosis that are unaffected by short-term exposure to air pollution (eg, carotid intima-media thickness [CIMT] and functional performance of the vessel). Air pollution studies using these end points are summarized. The CIMT is currently the most frequently used outcome in this field (6 studies). The continuous nature of CIMT, the lack of short-term variation, its relationship to atherosclerotic changes in the artery wall, its predictive value for coronary heart disease, and the noninvasiveness of the assessment make it a useful candidate for cross-sectional and longitudinal studies investigating the role of air pollution in atherogenesis.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Particulate matter; PM(2.5); Atherosclerosis; Cardiovascular diseases; Environment; Endothelial dysfunction; Air quality
ISSN (print) / ISBN
0033-0620
e-ISSN
1532-8643
Quellenangaben
Volume: 53,
Issue: 5,
Pages: 334-343
Publisher
Elsevier
Non-patent literature
Publications
Reviewing status
Peer reviewed