PuSH - Publication Server of Helmholtz Zentrum München: From atherosclerosis to myocardial infarction - a process-oriented model investigating the role of risk factors.

Information

Clues to quality of journals

Open Access Policy of Helmholtz Association 2016

CC Licencences

Publication Metrics

Navigation

Home

Deutsch

EVA: Electronic Publishing

New EVA Application

Research

Advanced Search

Browse by ...

... HMGU-Authors/Consortia

... Organizational Structure

... Journal

... Publication Type

... Research Data

... Arbeitsgruppen

... Publication Year

Publication overview

Statistics

Statistics (last 5 years)

OA Publications

Publish

Submit Publication

Import publication from...

...EVA

Report missing publication

Highlights

Support & Contact

Contact persons

Help

Data protection

Helmholtz Open Science

JANE Journal Estimator

SHERPA/RoMEO

DOAJ

Export:

Text

Endnote (RIS) BIB

BibTeX

Simonetto, C. ; Heier, M. ; Peters, A. ; Kaiser, J.C. ; Rospleszcz, S.

From atherosclerosis to myocardial infarction - a process-oriented model investigating the role of risk factors.

Am. J. Epidemiol. 191, 1766–1775 (2022)

Publ. Version/Full Text

Postprint

Research data

DOI

PMC

	Open Access Hybrid

Abstract
Metrics
Extra information

Mathematical models are able to reflect biological processes and to capture epidemiological data. Thus, they may help elucidating roles of risk factors in disease progression. We propose to account for smoking, hypertension and dyslipidemia in a previously published process-oriented model that de- scribes the development of atherosclerotic lesions resulting in myocardial infarction (MI). The model is sex-specific and incorporates individual heterogeneity. It was applied to population-based individual risk factors and MI rates (KORA study) together with subclinical atherosclerotic le-sion data (PDAY Study). Different model variants were evaluated testing the association of risk factors with different disease processes. Best fits were obtained for smoking affecting a late stage disease process, suggesting a thrombo-genic role. Hypertension was mainly related to complicated, vulnerable lesions. Dyslipidemia was con-sistent with increasing the number of initial lesions. By accounting for heterogeneity, individual hazard ratios differ from the population average. The mean individual hazard ratio for smoking was twice the population based hazard ratio for men, and even more for women. Atherosclerotic lesion progression and MI incidence data can be related in a mathematical model to illuminate how risk factors affect different phases of this pathological process.

Impact Factor

Scopus SNIP

Scopus
Cited By

Altmetric

5.363

0.000