PuSH - Publication Server of Helmholtz Zentrum München: Neuronal mitochondria transport <em>Pink1 </em>mRNA via synaptojanin 2 to support local mitophagy.

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Harbauer, A.B.* ; Hees, J.T.* ; Wanderoy, S.* ; Segura, I.* ; Gibbs, W.* ; Cheng, Y. ; Ordonez, M.* ; Cai, Z.* ; Cartoni, R.* ; Ashrafi, G.* ; Wang, C.* ; Perocchi, F. ; He, Z.* ; Schwarz, T.L.*

Neuronal mitochondria transport Pink1 mRNA via synaptojanin 2 to support local mitophagy.

Neuron 110, 1516-1531.e9 (2022)

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PTEN-induced kinase 1 (PINK1) is a short-lived protein required for the removal of damaged mitochondria through Parkin translocation and mitophagy. Because the short half-life of PINK1 limits its ability to be trafficked into neurites, local translation is required for this mitophagy pathway to be active far from the soma. The Pink1 transcript is associated and cotransported with neuronal mitochondria. In concert with translation, the mitochondrial outer membrane proteins synaptojanin 2 binding protein (SYNJ2BP) and synaptojanin 2 (SYNJ2) are required for tethering Pink1 mRNA to mitochondria via an RNA-binding domain in SYNJ2. This neuron-specific adaptation for the local translation of PINK1 provides distal mitochondria with a continuous supply of PINK1 for the activation of mitophagy.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Omp25 ; Pink1 ; Parkinson Disease ; Rna Transport ; Synj2bp ; Hitchhiking ; Local Translation ; Mitophagy ; Synaptojanin2

ISSN (print) / ISBN 0896-6273

e-ISSN 1097-4199

Journal Neuron

Quellenangaben Volume: 110, Issue: 9, Pages: 1516-1531.e9

Publisher Cell Press

Publishing Place Cambridge, Mass.

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Diabetes and Obesity (IDO)

Grants Max-Planck-Gesellschaft
Deutsche Forschungsgemeinschaft
Yale University
Harvard NeuroDiscovery Center
Jane Coffin Childs Memorial Fund for Medical Research
Howard Hughes Medical Institute
National Institutes of Health
Munich Center for Systems Neurology