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Harbauer, A.B.* ; Hees, J.T.* ; Wanderoy, S.* ; Segura, I.* ; Gibbs, W.* ; Cheng, Y. ; Ordonez, M.* ; Cai, Z.* ; Cartoni, R.* ; Ashrafi, G.* ; Wang, C.* ; Perocchi, F. ; He, Z.* ; Schwarz, T.L.*

Neuronal mitochondria transport Pink1 mRNA via synaptojanin 2 to support local mitophagy.

Neuron 110, 1516-1531.e9 (2022)
Postprint DOI PMC
Open Access Green
PTEN-induced kinase 1 (PINK1) is a short-lived protein required for the removal of damaged mitochondria through Parkin translocation and mitophagy. Because the short half-life of PINK1 limits its ability to be trafficked into neurites, local translation is required for this mitophagy pathway to be active far from the soma. The Pink1 transcript is associated and cotransported with neuronal mitochondria. In concert with translation, the mitochondrial outer membrane proteins synaptojanin 2 binding protein (SYNJ2BP) and synaptojanin 2 (SYNJ2) are required for tethering Pink1 mRNA to mitochondria via an RNA-binding domain in SYNJ2. This neuron-specific adaptation for the local translation of PINK1 provides distal mitochondria with a continuous supply of PINK1 for the activation of mitophagy.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Omp25 ; Pink1 ; Parkinson Disease ; Rna Transport ; Synj2bp ; Hitchhiking ; Local Translation ; Mitophagy ; Synaptojanin2
Language english
Publication Year 2022
HGF-reported in Year 2022
ISSN (print) / ISBN 0896-6273
e-ISSN 1097-4199
Journal Neuron
Quellenangaben Volume: 110, Issue: 9, Pages: 1516-1531.e9 Article Number: , Supplement: ,
Publisher Cell Press
Publishing Place Cambridge, Mass.
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Obesity (IDO)
POF-Topic(s) 30201 - Metabolic Health
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-502200-001
G-502295-001
Grants Max-Planck-Gesellschaft
Deutsche Forschungsgemeinschaft
Yale University
Harvard NeuroDiscovery Center
Jane Coffin Childs Memorial Fund for Medical Research
Howard Hughes Medical Institute
National Institutes of Health
Munich Center for Systems Neurology
DOI 10.1016/j.neuron.2022.01.035
WOS ID WOS:000802218100011
Scopus ID 85129382676
PubMed ID 35216662
Erfassungsdatum 2022-05-02
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