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von Krüchten, R.* ; Rospleszcz, S. ; Lorbeer, R.* ; Hasic, D.* ; Peters, A. ; Bamberg, F.* ; Schulz, H. ; Karrasch, S.* ; Schlett, C.L.*

Whole-body MRI-derived adipose tissue characterization and relationship to pulmonary function impairment.

Tomography 8, 560-569 (2022)

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	Open Access Gold

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Background: Specification of adipose tissues by whole-body magnetic resonance imaging (MRI) was performed and related to pulmonary function parameters in a population-based cohort. Methods: 203 study participants underwent whole-body MRI and pulmonary function tests as part of the KORA (Cooperative Health Research in the Augsburg Region) MRI study. Both visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were derived from the T1-Dixon sequence, and hepatic adipose tissue from the proton density fat fraction (PDFFhepatic). Associations between adipose tissue parameters and spirometric indices such as forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1) and Tiffeneau-index (FEV1/FVC) were examined using multivariate linear regression analysis excluding cofounding effects of other clinical parameters. Results: VAT (β = −0.13, p = 0.03) and SAT (β = −0.26, p < 0.001), but not PDFFhepatic were inversely associated with FEV1, while VAT (β = −0.27, p < 0.001), SAT (β = −0.41, p < 0.001), and PDFFhepatic (β = −0.17, p = 0.002) were inversely associated with FVC. PDFFhepatic was directly associated with the Tiffeneau index (β = 2.46, p < 0.001). Conclusions: In the adjusted linear regression model, VAT was inversely associated with all measured spirometric parameters, while PDFFhepatic revealed the strongest association with the Tiffeneau index. Non-invasive adipose tissue quantification measurements might serve as novel biomarkers for respiratory impairment.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Abdominal Fat Depots ; Hepatic Fat Content ; Lung Diseases ; Magnetic Resonance Imaging ; Respiratory Function Tests

ISSN (print) / ISBN 2379-1381

Journal Tomography

Quellenangaben Volume: 8, Issue: 2, Pages: 560-569

Publisher Grapho Publications

Publishing Place Ann Arbor, Michigan

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Epidemiology II (EPI2)
Institute of Epidemiology (EPI)

Grants Helmholtz Association
Federal Ministry of Education & Research (BMBF)
State of Bavaria
German Research Foundation (DFG)
German Centre for Diabetes Research (DZD, Neuherberg Germany)
German Centre for Cardiovascular Disease Research (DZHK, Berlin, Germany)
German Center for Lung Research (DZL)