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Early biomarkers and intervention programs for the infant exposed to prenatal stress.
Curr. Neuropharmacol. 20, 94-106 (2022)
Functional development of affective and reward circuits, cognition and response inhibition later in life exhibits vulnerability periods during gestation and early childhood. Extensive evidence supports the model that exposure to stressors in the gestational period and early postnatal life increases an individual's susceptibility to future impairments of functional development. Recent versions of this model integrate epigenetic mechanisms of the developmental response. Their understanding will guide the future treatment of the associated neuropsychiatric disorders. A combination of non-invasively obtainable physiological signals and epigenetic biomarkers related to the principal systems of the stress response, the Hypothalamic-Pituitary axis (HPA) and the Autonomic Nervous System (ANS), are emerging as the key predictors of neurodevelopmental outcomes. Such electrophysiological and epigenetic biomarkers can prove to timely identify children benefiting most from early intervention programs. Such programs should ameliorate future disorders in otherwise healthy children. The recently developed Early Family-Centered Intervention Programs aim to influence the care and stimuli provided daily by the family and improving parent/child attachment, a key element for healthy socio-emotional adult life. Although frequently underestimated, such biomarker-guided early intervention strategy represents a crucial first step in the prevention of future neuropsychiatric problems and in reducing their personal and societal impact.
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Publication type
Article: Journal article
Document type
Review
Keywords
Maternal Stress ; Epigenetic Biomarkers ; Fhr ; Prsa ; Early Intervention Programs ; Neurodevelopment; Fetal Heart-rate; Maternal Stress; Dna Methylation; Developmental Origins; Glucocorticoid-receptor; Mental-health; Epigenetic Changes; Rate-variability; Gene-expression; Follow-up
ISSN (print) / ISBN
1570-159X
e-ISSN
1875-6190
Journal
Current neuropharmacology
Quellenangaben
Volume: 20,
Issue: 1,
Pages: 94-106
Publisher
Bentham Science Publishers
Publishing Place
San Francisco, Calif.
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Epidemiology II (EPI2)
Grants
Hans Fischer Senior Fellowship from IAS-TUM (Institute for Advanced Study-TUM, Munich, Germany)
Klinik und Poliklinik far Frauenheilkunde, TUM, Klinikum-rechts der Isar, Munich, Germany
Klinik und Poliklinik far Frauenheilkunde, TUM, Klinikum-rechts der Isar, Munich, Germany