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Open Access Green as soon as Postprint is submitted to ZB.
Cyclin D1 positive diffuse large B-cell lymphoma is a post-germinal center-type lymphoma without alterations in the CCND1 gene locus.
Leuk. Lymphoma 52, 458-466 (2011)
The aims of this study were to analyze the incidence and morphology of cyclin D1+ DLBCL and cases of Richter transformation (RT), and to elucidate possible molecular mechanisms of cyclin D1 overexpression. Seventy-two cases of de novo DLBCL and 12 cases of RT were included in this study. Cyclin D1 positivity was found in 10/66 (15%) cases of unselected de novo DLBCL and in 2/11 (18%) cases of RT. Seven independently identified cases of cyclin D1+ DLBCL, including one RT, were added to the study. Centroblastic morphology was found in 17/19 (89%) cases of cyclin D1+, most with a post-germinal center phenotype (CD10-, BCL6+, MUM1+). No alterations in the CCND1 gene indicative for a translocation t(11;14) were identified by FISH. Analysis of the MYC locus yielded gene copy alterations in five cases and no disruption of the gene locus in any case, suggesting an alternative mechanism of cyclin D1 deregulation.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Multiple-myeloma; Protein expression; Overexpression; Progression; Activation; Binding; G(1); BCL6
ISSN (print) / ISBN
1042-8194
e-ISSN
1029-2403
Journal
Leukemia and Lymphoma
Quellenangaben
Volume: 52,
Issue: 3,
Pages: 458-466
Publisher
Informa Healthcare
Non-patent literature
Publications
Reviewing status
Peer reviewed