Home
Deutsch
Advanced Search
Browse by ...
Publication overview
Contact persons
Help
Publ. Version/Full Text
DOI
PMC
 |
Open Access Gold |
|
as soon as is submitted to ZB.
De-novo and depot-specific androgen production in human adipose tissue - a source of hyperandrogenism in women with obesity.
Obes. Facts 15, 281-291 (2022)
Introduction: Obesity in women is often associated with hyperandrogenism, but the role of adipose tissue (AT) in androgen synthesis remains unclear. Therefore, we studied whether AT could be a source of androgens promoting hyperandrogenism. Methods: Subcutaneous and visceral (visc) AT was collected from lean and obese women. Androgen levels were evaluated in serum, AT, and cell-culture supernatant. Gene and protein expression of steroidogenic enzymes were determined. Results: Obese subjects had elevated serum androgen levels, which reduced after weight loss. Androgens were measurable in AT and in cell-culture supernatants of adipocytes. Steroids were higher in AT from obese women, with the highest difference for testosterone in visc AT (+7.9-fold, p = 0.032). Steroidogenic enzymes were expressed in human AT with depot-specific differences. Obese women showed a significantly higher expression of genes of the backdoor pathway and of CYP19 in visc AT. Conclusion: The whole steroidogenic machinery of the classical and backdoor pathways of steroidogenesis, and the capacity for androgen biosynthesis, were found in both AT depots and cultured adipocytes. Therefore, we hypothesize that AT is a de novo site of androgen production and the backdoor pathway of steroidogenesis might be a new pathomechanism for hyperandrogenism in women with obesity.
Altmetric
Additional Metrics?
Edit extra informations
Login
Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Adipocytes ; Androgens ; Hyperandrogenism In Women ; Obesity ; Steroidogenic Capacity
ISSN (print) / ISBN
1662-4025
e-ISSN
1662-4033
Journal
Obesity Facts
Quellenangaben
Volume: 15,
Issue: 2,
Pages: 281-291
Publisher
Karger
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Helmholtz Institute for Metabolism, Obesity and Vascular Research (HI-MAG)
Grants
Universidad de las Fuerzas Armadas ESPE
Vetenskapsrådet
Institut Français de Bioinformatique
Horizon 2020 Framework Programme
European Society for Paediatric Endocrinology
Kronprinsessan Lovisas Foundation
Frimurare Barnhuset Foundation
Vetenskapsrådet
Institut Français de Bioinformatique
Horizon 2020 Framework Programme
European Society for Paediatric Endocrinology
Kronprinsessan Lovisas Foundation
Frimurare Barnhuset Foundation