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Is hypoimmunogenic stem cell therapy safe in times of pandemics?
Stem Cell Rep. 17, 711-714 (2022)
The manipulation of human leukocyte antigens (HLAs) and immune modulatory factors in “universal” human pluripotent stem cells (PSCs) holds promise for immunological tolerance without HLA matching. This paradigm raises concerns should “universal” grafts become virally infected. Furthermore, immunological manipulation might functionally impair certain progeny, such as hematopoietic stem cells. We discuss the risks and benefits of hypoimmunogenic PSCs, and the need to further advance HLA matching and autologous strategies.
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Publication type
Article: Journal article
Document type
Review
ISSN (print) / ISBN
2213-6711
Journal
Stem Cell Reports
Quellenangaben
Volume: 17,
Issue: 4,
Pages: 711-714
Publisher
Cell Press
Publishing Place
Maryland Heights, MO
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Stem Cell Research (ISF)