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From observing children in traditional upbringing to concepts of health.
Progress in Inflammation Research 89, 1-26 (2022)
Studies in rural areas of developing countries and the farm studies have generated a rich texture of investigations on how traditional lifestyles in natural environments can protect children from developing asthma and allergic diseases. Many environmental exposures, be it from plants, animals, parasites, or microbial sources, are likely to contribute to protection, but the underlying pathways have not been fully understood. While involvement of the first line of defense, i.e., the multiple components of innate immunity, has been described to some extent, the interaction with and the consequences for adaptive immunity eventually deviating from asthma- and allergy-related Th2 immunity are not understood. The human skin, airway, and gut microbiome, as the interface between the external environment and its microbiome, and the host’s immune responses are likely to play an essential mediating role in this process. The findings call for novel avenues to prevention since both epidemiology and the associated experimental studies have reproducibly shown that mice and children can be almost fully protected from these conditions. The best approaches to prevention are however still debated, and this chapter will address a number of potential options.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Allergies ; Asthma ; Children ; Farm ; Microbiome
ISSN (print) / ISBN
1422-7746
e-ISSN
2296-4525
Book Volume Title
Evolution, Biodiversity and a Reassessment of the Hygiene Hypothesis
Quellenangaben
Volume: 89,
Pages: 1-26
Publisher
Springer
Non-patent literature
Publications
Institute(s)
Institute of Asthma and Allergy Prevention (IAP)