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Fischer, A. ; Wannemacher, J. ; Christ, S. ; Koopmans, T.* ; Kadri, S. ; Zhao, J. ; Gouda, M. ; Ye, H. ; Mück-Häusl, M. ; Krenn, P.W.* ; Machens, H.* ; Faessler, R.* ; Neumann, P.* ; Hauck, S.M. ; Rinkevich, Y.

Neutrophils direct preexisting matrix to initiate repair in damaged tissues.

Nat. Immunol. 23, 518-531 (2022)
Publ. Version/Full Text Research data DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
Internal organs heal injuries with new connective tissue, but the cellular and molecular events of this process remain obscure. By tagging extracellular matrix around the mesothelium lining in mouse peritoneum, liver and cecum, here we show that preexisting matrix was transferred across organs into wounds in various injury models. Using proteomics, genetic lineage-tracing and selective injury in juxtaposed organs, we found that the tissue of origin for the transferred matrix likely dictated the scarring or regeneration of the healing tissue. Single-cell RNA sequencing and genetic and chemical screens indicated that the preexisting matrix was transferred by neutrophils dependent on the HSF-integrin AM/B2-kindlin3 cascade. Pharmacologic inhibition of this axis prevented matrix transfer and the formation of peritoneal adhesions. Matrix transfer was thus an early event of wound repair and provides a therapeutic window to dampen scaring across a range of conditions.
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Publication type Article: Journal article
Document type Scientific Article
Language english
Publication Year 2022
HGF-reported in Year 2022
ISSN (print) / ISBN 1529-2908
e-ISSN 1529-2916
Journal Nature Immunology
Quellenangaben Volume: 23, Issue: 4, Pages: 518-531 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Reviewing status Peer reviewed
Institute(s) Institute of Regenerative Biology and Medicine (IRBM)
CF Metabolomics & Proteomics (CF-MPC)
POF-Topic(s) 30202 - Environmental Health
30203 - Molecular Targets and Therapies
Research field(s) Lung Research
Enabling and Novel Technologies
PSP Element(s) G-509400-001
G-505700-001
Grants
Deutsche Forschungsgemeinschaft (German Research Foundation)
Human Frontier Science Program (HFSP)
DOI 10.1038/s41590-022-01166-6
WOS ID WOS:000775781500003
PubMed ID 35354953
Erfassungsdatum 2022-04-28
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