PuSH - Publication Server of Helmholtz Zentrum München: Preparations of intravenous immunoglobulins diminish the number and proinflammatory response of CD14<sup>+</sup>CD16<sup>++ </sup>monocytes in common variable immunodeficiency (CVID) patients.

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Siedlar, M.* ; Strach, M.* ; Bukowska-Strakova, K.* ; Lenart, M.* ; Szaflarska, A.* ; Węglarczyk, K.* ; Rutkowska, M.* ; Baj-Krzyworzeka, M.* ; Pituch-Noworolska, A.* ; Kowalczyk, D.* ; Grodzicki, T.* ; Ziegler-Heitbrock, L. ; Zembala, M.*

Preparations of intravenous immunoglobulins diminish the number and proinflammatory response of CD14⁺CD16⁺⁺monocytes in common variable immunodeficiency (CVID) patients.

Clin. Immunol. 139, 122-132 (2011)

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Open Access Green as soon as Postprint is submitted to ZB.

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We have studied the effect of intravenous immunoglobulins (IVIG) on monocyte subpopulations and cytokine production in patients with CVID. The absolute number of CD14(+)CD16(++) monocytes decreased on average 2.5-fold 4h after IVIG and after 20h returned to the baseline. The cytokine level in the supernatants of peripheral blood mononuclear cells (PBMC) after ex vivo LPS stimulation demonstrated the >2-fold decrease in TNF production 4h after IVIG. The TNF expression, which is higher in the CD14(+)CD16(++) monocytes, was decreased in these cells by IVIG in 4/7 CVID cases. In vitro exposure of the healthy individuals' monocytes to the IVIG preparation resulted in reduced TNF production, which was overcome by blockade of the FcγRIIB in the CD14(+)CD16(++) CD32B(high) monocytes. Our data suggest that reduction in the number of CD14(+)CD16(++) monocytes and the blockade of their cytokine production via triggering CD32B can contribute to the anti-inflammatory action of IVIG.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords CD14(+)CD16(++) monocytes; Intravenous immunoglobulins; CD32B; Common variable immunodeficiency

ISSN (print) / ISBN 1521-6616

e-ISSN 1521-7035

Journal Clinical Immunology

Quellenangaben Volume: 139, Issue: 2, Pages: 122-132

Publisher Elsevier

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Lung Health and Immunity (LHI)

PuSH - Publication Server of Helmholtz Zentrum München

Preparations of intravenous immunoglobulins diminish the number and proinflammatory response of CD14+CD16++ monocytes in common variable immunodeficiency (CVID) patients.

Preparations of intravenous immunoglobulins diminish the number and proinflammatory response of CD14⁺CD16⁺⁺monocytes in common variable immunodeficiency (CVID) patients.