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Müller-Eigner, A.* ; Sanz-Moreno, A. ; de-Diego, I.* ; Venkatasubramani, A.V.* ; Langhammer, M.* ; Gerlini, R. ; Rathkolb, B. ; Aguilar-Pimentel, J.A. ; Klein-Rodewald, T. ; Calzada-Wack, J. ; Becker, L. ; Palma-Vera, S.* ; Gille, B.* ; Forne, I.* ; Imhof, A.* ; Meng, C.* ; Ludwig, C.* ; Koch, F.* ; Heiker, J.T. ; Kuhla, A.* ; Caton, V.* ; Brenmoehl, J.* ; Reyer, H.* ; Schoen, J.* ; Fuchs, H. ; Gailus-Durner, V. ; Hoeflich, A.* ; Hrabě de Angelis, M. ; Peleg, S.*

Dietary intervention improves health metrics and life expectancy of the genetically obese Titan mouse.

Comm. Biol. 5:408 (2022)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Suitable animal models are essential for translational research, especially in the case of complex, multifactorial conditions, such as obesity. The non-inbred mouse (Mus musculus) line Titan, also known as DU6, is one of the world’s longest selection experiments for high body mass and was previously described as a model for metabolic healthy (benign) obesity. The present study further characterizes the geno- and phenotypes of this non-inbred mouse line and tests its suitability as an interventional obesity model. In contrast to previous findings, our data suggest that Titan mice are metabolically unhealthy obese and short-lived. Line-specific patterns of genetic invariability are in accordance with observed phenotypic traits. Titan mice also show modifications in the liver transcriptome, proteome, and epigenome linked to metabolic (dys)regulations. Importantly, dietary intervention partially reversed the metabolic phenotype in Titan mice and significantly extended their life expectancy. Therefore, the Titan mouse line is a valuable resource for translational and interventional obesity research.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
ISSN (print) / ISBN 2399-3642
e-ISSN 2399-3642
Journal Communications Biology
Quellenangaben Volume: 5, Issue: 1, Pages: , Article Number: 408 Supplement: ,
Publisher Springer
Publishing Place London
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Experimental Genetics (IEG)
Helmholtz Institute for Metabolism, Obesity and Vascular Research (HI-MAG)
Grants Bundesministerium für Bildung und Forschung
National Natural Science Foundation of China
Deutsche Forschungsgemeinschaft
Norn Group
Karin Ullerich
Helmholtz Alliance
German Center for Diabetes Research