PuSH - Publication Server of Helmholtz Zentrum München

Smith, J.G.* ; Sato, T.* ; Shimaji, K.* ; Koronowski, K.B.* ; Petrus, P.* ; Cervantes, M.* ; Kinouchi, K.* ; Lutter, D. ; Dyar, K.A. ; Sassone-Corsi, P.*

Antibiotic-induced microbiome depletion remodels daily metabolic cycles in the brain.

Life Sci. 303:120601 (2022)
Publ. Version/Full Text DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
The gut microbiome influences cognition and behavior in mammals, yet its metabolic impact on the brain is only starting to be defined. Using metabolite profiling of antibiotics-treated mice, we reveal the microbiome as a key input controlling circadian metabolic cycles in the brain. Intra and inter-region analyses characterise the influence of the microbiome on the suprachiasmatic nucleus, containing the central clockwork, as well as the hippocampus and cortex, regions involved in learning and behavior.
Altmetric
Additional Metrics?
[➜Log in]
Edit extra informations Login
Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Circadian ; Gut-brain Axis ; Metabolism ; Microbiome ; Neurometabolism ; Systems Biology
ISSN (print) / ISBN 0024-3205
e-ISSN 1879-0631
Journal Life Sciences
Quellenangaben Volume: 303, Issue: , Pages: , Article Number: 120601 Supplement: ,
Publisher Elsevier
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Obesity (IDO)
Institute of Diabetes and Cancer (IDC)