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Okbay, A.* ; Wu, Y.* ; Wang, N.* ; Jayashankar, H.* ; Bennett, M.J.* ; Nehzati, S.M.* ; Sidorenko, J.* ; Kweon, H.* ; Goldman, G.* ; Gjorgjieva, T.* ; Jiang, Y.* ; Hicks, B.* ; Tian, C.* ; Hinds, D.A.* ; Ahlskog, R.* ; Magnusson, P.K.E.* ; Oskarsson, S.* ; Hayward, C.* ; Campbell, A.* ; Porteous, D.J.* ; Freese, J.* ; Herd, P.* ; Watson, C.R.* ; Jala, J.* ; Conley, D.* ; Koellinger, P.D.* ; Johannesson, M.* ; Laibson, D.* ; Meyer, M.N.* ; Lee, J.J.* ; Kong, A.* ; Yengo, L.* ; Cesarini, D.* ; Turley, P.* ; Visscher, P.M.* ; Beauchamp, J.P.* ; Benjamin, D.J.* ; Young, A.I.* ; Social Science Genetic Association Consortium (Gieger, C. ; Baumbach, C. ; Meisinger, C. ; Meitinger, T. ; Lichtner, P. ; Strauch, K.)

Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals.

Nat. Genet. 54, 437-449 (2022)

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We conduct a genome-wide association study (GWAS) of educational attainment (EA) in a sample of ~3 million individuals and identify 3,952 approximately uncorrelated genome-wide-significant single-nucleotide polymorphisms (SNPs). A genome-wide polygenic predictor, or polygenic index (PGI), explains 12-16% of EA variance and contributes to risk prediction for ten diseases. Direct effects (i.e., controlling for parental PGIs) explain roughly half the PGI's magnitude of association with EA and other phenotypes. The correlation between mate-pair PGIs is far too large to be consistent with phenotypic assortment alone, implying additional assortment on PGI-associated factors. In an additional GWAS of dominance deviations from the additive model, we identify no genome-wide-significant SNPs, and a separate X-chromosome additive GWAS identifies 57.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

ISSN (print) / ISBN 1061-4036

e-ISSN 1546-1718

Journal Nature Genetics

Quellenangaben Volume: 54, Issue: 4, Pages: 437-449

Publisher Nature Publishing Group

Publishing Place New York, NY

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Epidemiology II (EPI2)
Institute of Human Genetics (IHG)
Institute of Genetic Epidemiology (IGE)

Grants Riksbankens Jubileumsfond (Stiftelsen Riksbankens Jubileumsfond)
RCUK | Medical Research Council (MRC)
Genome Canada (Génome Canada)
Department of Education and Training | Australian Research Council (ARC)
Ragnar Söderbergs stiftelse (Ragnar Söderberg Foundation)
NIMH NIH HHS
U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging)
Department of Health | National Health and Medical Research Council (NHMRC)
NIA NIH HHS