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Local problems need global solutions - the metabolic needs of regenerating organisms.
Wound Repair Regen. 30, 652-664 (2022)
The vast majority of species that belong to the plant or animal kingdom evolved with two main strategies to counter tissue damage - scar formation and regeneration. Whereas scar formation provides a fast and cost-effective repair to exit life-threatening conditions, complete tissue regeneration is time-consuming and requires vast resources to reinstall functionality of affected organs or structures. Local environments in wound healing are widely studied and findings have provided important biomedical applications. Less well understood are organismic physiological parameters and signaling circuits essential to maintain effective tissue repair. Here, we review accumulated evidence that positions the interplay of local and systemic changes in metabolism as essential variables modulating the injury response. We particularly emphasize the role of lipids and lipid-like molecules as significant components long overlooked.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Insulin ; Lipids ; Metabolism ; Regeneration ; Systemic Response
ISSN (print) / ISBN
1067-1927
e-ISSN
1524-475X
Journal
Wound repair and regeneration
Quellenangaben
Volume: 30,
Issue: 6,
Pages: 652-664
Publisher
Wiley
Publishing Place
Hoboken, NJ.
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute for Pancreatic Beta Cell Research (IPI)
Grants
Medical Research Council, as part ofUK Research and Innovation
Deutsche Forschungsgemeinscha
Deutsche Forschungsgemeinscha