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Habener, A.* ; Grychtol, R.* ; Gaedcke, S.* ; Deluca, D.* ; Dittrich, A.M.* ; Happle, C.* ; Abdo, M.* ; Watz, H.* ; Pedersen, F.* ; König, I.R.* ; Thiele, D.* ; Kopp, M.V.* ; von Mutius, E. ; Bahmer, T.* ; Rabe, K.F.* ; Meyer-Bahlburg, A.* ; Hansen, G.* ; ALLIANCE Study Group (Zissler, U.M. ; Maison, N. ; Illi, S. ; Marzi, C. ; Schmidt-Weber, C.B.)

IgA+ memory B cells are significantly increased in patients with asthma and small airways dysfunction.

Eur. Respir. J. 60:2102130 (2022)
Publ. Version/Full Text Postprint Research data DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
BACKGROUND: Comprehensive studies investigated the role of T cells in asthma leading to personalised treatment options targeting severe eosinophilic asthma. However, little is known about the contribution of B cells to this chronic inflammatory disease. In this study, we investigated the contribution of various B cell populations to specific clinical features in asthma. METHODS: In the All Age Asthma Cohort (ALLIANCE) a subgroup of 154 adult asthma patients and 28 healthy controls were included for B cell characterisation by flow cytometry. Questionnaires, lung function measurements, blood differential counts and allergy testing of participants were analysed together with comprehensive data on B cells via association studies and multivariate linear models. RESULTS: Patients with severe asthma showed decreased immature B cell populations while memory B cells were significantly increased compared to both mild-moderate asthma patients and healthy controls. Furthermore, increased frequencies of immunoglobulin A positive (IgA+) memory B cells were associated with impaired lung function and specifically with parameters indicative for augmented resistance in the peripheral airways. Accordingly, asthma patients with small airway dysfunction (SAD) defined by impulse oscillometry showed increased frequencies of IgA+ memory B cells, particularly in patients with mild to moderate asthma. Additionally, IgA+ memory B cells significantly correlated with clinical features of SAD such as exacerbations. CONCLUSIONS: With this study we demonstrate for the first time a significant association of increased IgA+ memory B cells with asthma and SAD, pointing towards future options for B cell-directed strategies in preventing and treating asthma.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
ISSN (print) / ISBN 0903-1936
e-ISSN 1399-3003
Journal European Respiratory Journal
Quellenangaben Volume: 60, Issue: 5, Pages: , Article Number: 2102130 Supplement: ,
Publisher European Respiratory Society
Publishing Place Sheffield
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Asthma and Allergy Prevention (IAP)
Institute for Allergy Research (IAF)
Grants German Research Foundation
Cluster of Excellence RESIST
German Center for Lung Research
Federal Ministry of Education and Research