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Oda, H.* ; Roth, H.R.* ; Chiba, K.* ; Sokolić, J.* ; Kitasaka, T.* ; Oda, M.* ; Hinoki, A.* ; Uchida, H.* ; Schnabel, J.A.* ; Mori, K.*

BESNet: Boundary-enhanced segmentation of cells in histopathological images.

In: (International Conference on Medical Image Computing and Computer-Assisted Intervention). Berlin [u.a.]: Springer, 2018. 228-236 (Lect. Notes Comput. Sc. ; 11071 LNCS)
DOI
Open Access Green as soon as Postprint is submitted to ZB.
We propose a novel deep learning method called Boundary-Enhanced Segmentation Network (BESNet) for the detection and semantic segmentation of cells on histopathological images. The semantic segmentation of small regions using fully convolutional networks typically suffers from inaccuracies around the boundaries of small structures, like cells, because the probabilities often become blurred. In this work, we propose a new network structure that encodes input images to feature maps similar to U-net but utilizes two decoding paths that restore the original image resolution. One decoding path enhances the boundaries of cells, which can be used to improve the quality of the entire cell segmentation achieved in the other decoding path. We explore two strategies for enhancing the boundaries of cells: (1) skip connections of feature maps, and (2) adaptive weighting of loss functions. In (1), the feature maps from the boundary decoding path are concatenated with the decoding path for entire cell segmentation. In (2), an adaptive weighting of the loss for entire cell segmentation is performed when boundaries are not enhanced strongly, because detecting such parts is difficult. The detection rate of ganglion cells was 80.0% with 1.0 false positives per histopathology slice. The mean Dice index representing segmentation accuracy was 74.0%. BESNet produced a similar detection performance and higher segmentation accuracy than comparable U-net architectures without our modifications.
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Publication type Article: Conference contribution
Corresponding Author
ISSN (print) / ISBN 0302-9743
e-ISSN 1611-3349
Conference Title International Conference on Medical Image Computing and Computer-Assisted Intervention
Journal Lecture Notes in Computer Science
Quellenangaben Volume: 11071 LNCS, Issue: , Pages: 228-236 Article Number: , Supplement: ,
Publisher Springer
Publishing Place Berlin [u.a.]
Non-patent literature Publications
Institute(s) Institute for Machine Learning in Biomed Imaging (IML)