PuSH - Publication Server of Helmholtz Zentrum München: Pieces-of-parts for supervoxel segmentation with global context: Application to DCE-MRI tumour delineation.

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Irving, B.* ; Franklin, J.M.* ; Papiez, B.W.* ; Anderson, E.M.* ; Sharma, R.A.* ; Gleeson, F.V.* ; Brady, S.M.* ; Schnabel, J.A.*

Pieces-of-parts for supervoxel segmentation with global context: Application to DCE-MRI tumour delineation.

Med. Image Anal. 32, 69-83 (2016)

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Rectal tumour segmentation in dynamic contrast-enhanced MRI (DCE-MRI) is a challenging task, and an automated and consistent method would be highly desirable to improve the modelling and prediction of patient outcomes from tissue contrast enhancement characteristics - particularly in routine clinical practice. A framework is developed to automate DCE-MRI tumour segmentation, by introducing: perfusion-supervoxels to over-segment and classify DCE-MRI volumes using the dynamic contrast enhancement characteristics; and the pieces-of-parts graphical model, which adds global (anatomic) constraints that further refine the supervoxel components that comprise the tumour. The framework was evaluated on 23 DCE-MRI scans of patients with rectal adenocarcinomas, and achieved a voxelwise area-under the receiver operating characteristic curve (AUC) of 0.97 compared to expert delineations. Creating a binary tumour segmentation, 21 of the 23 cases were segmented correctly with a median Dice similarity coefficient (DSC) of 0.63, which is close to the inter-rater variability of this challenging task. A second study is also included to demonstrate the method's generalisability and achieved a DSC of 0.71. The framework achieves promising results for the underexplored area of rectal tumour segmentation in DCE-MRI, and the methods have potential to be applied to other DCE-MRI and supervoxel segmentation problems.

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