PuSH - Publication Server of Helmholtz Zentrum München: Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: First in-human results.

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van Dam, G.M.* ; Themelis, G. ; Crane, L.M.* ; Harlaar, N.J. ; Pleijhuis, R.G.* ; Kelder, W.* ; Sarantopoulos, A. ; de Jong, J.S.* ; Arts, H.J.* ; van der Zee, A.G.* ; Bart, J.* ; Low, P.S.* ; Ntziachristos, V.

Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: First in-human results.

J. Nat. Med. 17, 1315-1319 (2011)

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The prognosis in advanced-stage ovarian cancer remains poor. Tumor-specific intraoperative fluorescence imaging may improve staging and debulking efforts in cytoreductive surgery and thereby improve prognosis. The overexpression of folate receptor-α (FR-α) in 90-95% of epithelial ovarian cancers prompted the investigation of intraoperative tumor-specific fluorescence imaging in ovarian cancer surgery using an FR-α-targeted fluorescent agent. In patients with ovarian cancer, intraoperative tumor-specific fluorescence imaging with an FR-α-targeted fluorescent agent showcased the potential applications in patients with ovarian cancer for improved intraoperative staging and more radical cytoreductive surgery.

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