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Tiamani, K. ; Luo, S. ; Schulz, S. ; Xue, J. ; Costa, R. ; Mirzaei, M.K. ; Deng, L.

The role of virome in the gastrointestinal tract and beyond.

FEMS Microbiol. Rev. 46:fuac027 (2022)
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The human gut virome is comprised of diverse commensal and pathogenic viruses. The colonization by these viruses begins right after birth through vaginal delivery, then continues through breastfeeding, and broader environmental exposure. Their constant interaction with their bacterial hosts in the body shapes not only our microbiomes but us. In addition, these viruses interact with the immune cells, trigger a broad range of immune responses, and influence different metabolic pathways. Besides its key role in regulating the human gut homeostasis, the intestinal virome contributes to disease development in distant organs, both directly and indirectly. In this review, we will describe the changes in the gut virome through life, health, and disease, followed by discussing the interactions between the virome, the microbiome, and the human host as well as providing an overview of their contribution to gut disease and disease of distant organs.
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Publication type Article: Journal article
Document type Review
Keywords Virome ; Microbiome ; Gastrointestinal Tract ; Phageome ; Immune Response ; Auxiliary Metabolic Genes
Language english
Publication Year 2022
HGF-reported in Year 2022
ISSN (print) / ISBN 0168-6445
Journal FEMS Microbiology Reviews - Federation of European Microbiological Societies
Quellenangaben Volume: 46, Issue: 6, Pages: , Article Number: fuac027 Supplement: ,
Publisher Wiley
Publishing Place Malden, Mass.
Reviewing status Peer reviewed
Institute(s) Institute of Virology (VIRO)
POF-Topic(s) 30203 - Molecular Targets and Therapies
Research field(s) Immune Response and Infection
PSP Element(s) G-554300-001
DOI 10.1093/femsre/fuac027
WOS ID WOS:000846448700001
Scopus ID 85141208702
PubMed ID 35700129
Erfassungsdatum 2022-07-06
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