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Ikonomou, L.* ; Magnusson, M.* ; Dries, R.* ; Herzog, E.L.* ; Hynds, R.* ; Borok, Z.* ; Park, J.A.* ; Skolasinski, S.* ; Burgess, J.K.* ; Turner, L.* ; Mojarad, S.M.* ; Mahoney, J.E.* ; Lynch, T.* ; Lehmann, M. ; Thannickal, V.J.* ; Hook, J.L.* ; Vaughan, A.E.* ; Hoffman, E.T.* ; Weiss, D.J.* ; Ryan, A.L.*

Stem cells, cell therapies, and bioengineering in lung biology and disease 2021.

Am. J. Physiol. Lung Cell Mol. Physiol. 323, L341-L354 (2022)
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The 9th biennial conference titled "Stem Cells, Cell Therapies, and Bioengineering in Lung Biology and Diseases" was hosted virtually, due to the ongoing COVID-19 pandemic, in collaboration with the University of Vermont Larner College of Medicine, the National Heart, Lung, and Blood Institute, the Alpha-1 Foundation, the Cystic Fibrosis Foundation, and the International Society for Cell & Gene Therapy. The event was held from July 12th through 15th, 2021 with a pre-conference workshop held July 9th. As in previous years the objectives remained to review and discuss the status of active research areas involving stem cells, cellular therapeutics, and bioengineering as they relate to the human lung. Topics included: 1) technological advancements in the in situ analysis of lung tissues, 2) new insights into stem cell signalling and plasticity in lung remodelling and regeneration, 3) the impact of extracellular matrix in stem cell regulation and airway engineering in lung regeneration, 4) differentiating and delivering stem cell therapeutics to the lung, 5) regeneration in response to viral infection, and 6) ethical development of cell-based treatments for lung diseases. This selection of topics represents some of the most dynamic and current research areas in lung biology. The virtual workshop included active discussion on state-of-the-art methods relating to the core features of the 2021 conference, including in-situ protemics, lung-on-chip, iPSC-airway differentiation, and light sheet microscopy. The conference concluded with an open discussion to suggest funding priorities and recommendations for future research directions in basic and translational lung biology.
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Publication type Article: Journal article
Document type Review
Keywords Bioengineering ; Extracellular Matrix ; Lung Regeneration ; Pluripotent Stem Cells ; Proteomics
Language english
Publication Year 2022
HGF-reported in Year 2022
ISSN (print) / ISBN 1040-0605
e-ISSN 1522-1504
Journal American Journal of Physiology - Lung Cellular and Molecular Physiology
Quellenangaben Volume: 323, Issue: 3, Pages: L341-L354 Article Number: , Supplement: ,
Publisher American Physiological Society
Publishing Place Bethesda, Md. [u.a.]
Reviewing status Peer reviewed
Institute(s) Institute of Lung Health and Immunity (LHI)
POF-Topic(s) 80000 - German Center for Lung Research
30202 - Environmental Health
Research field(s) Lung Research
PSP Element(s) G-501800-311
G-503100-001
Grants HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI)
DOI 10.1152/ajplung.00113.2022
WOS ID WOS:000894265200001
Scopus ID 85138442663
PubMed ID 35762622
Erfassungsdatum 2022-09-26
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