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HIV-1 Nef increases astrocyte sensitivity towards exogenous hydrogen peroxide.
Virol. J. 8:35 (2011)
BACKGROUND: HIV-1 infected individuals are under chronic exposure to reactive oxygen species (ROS) considered to be instrumental in the progression of AIDS and the development of HIV-1 associated dementia (HAD). Astrocytes support neuronal function and protect them against cytotoxic substances including ROS. The protein HIV-1 Nef, a progression factor in AIDS pathology is abundantly expressed in astrocytes in patients with HAD, and thus may influence its functions. RESULTS: Endogenous expressed HIV-1 Nef leads to increased sensitivity of human astrocytes towards exogenous hydrogen peroxide but not towards TNF-alpha. Cell death of nef-expressing astrocytes exposed to 10 μM hydrogen peroxide for 30 min occurred within 4 h. CONCLUSION: HIV-1 Nef may contribute to neuronal dysfunction and the development of HAD by causing death of astrocytes through decreasing their tolerance for hydrogen peroxide.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Human-immunodeficiency-virus; Cental-nervous-system; Aids-like disease; Oxidative stress; Cell-death; Chemottractant protein-1; Glutathione-peroxidase-peroxidase; Potential mechanism; Dependent manner; Transgenic mice
e-ISSN
1743-422x
Journal
Virology Journal
Quellenangaben
Volume: 8,
Article Number: 35
Publisher
BioMed Central
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Virology (VIRO)