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A Riemannian approach to predicting brain function from the structural connectome.
Neuroimage 257:119299 (2022)
Ongoing brain function is largely determined by the underlying wiring of the brain, but the specific rules governing this relationship remain unknown. Emerging literature has suggested that functional interactions between brain regions emerge from the structural connections through mono- as well as polysynaptic mechanisms. Here, we propose a novel approach based on diffusion maps and Riemannian optimization to emulate this dynamic mechanism in the form of random walks on the structural connectome and predict functional interactions as a weighted combination of these random walks. Our proposed approach was evaluated in two different cohorts of healthy adults (Human Connectome Project, HCP; Microstructure-Informed Connectomics, MICs). Our approach outperformed existing approaches and showed that performance plateaus approximately around the third random walk. At macroscale, we found that the largest number of walks was required in nodes of the default mode and frontoparietal networks, underscoring an increasing relevance of polysynaptic communication mechanisms in transmodal cortical networks compared to primary and unimodal systems.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Diffusion Maps ; Functional Connectivity ; Manifold Optimization ; Structural Connectome
ISSN (print) / ISBN
1053-8119
e-ISSN
1095-9572
Quellenangaben
Volume: 257,
Article Number: 119299
Publisher
Elsevier
Reviewing status
Peer reviewed
Institute(s)
Helmholtz AI - FZJ (HAI - FZJ)