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Principles of mRNA transport in yeast.
Cell. Mol. Life Sci. 69, 1843-1853 (2012)
mRNA localization and localized translation is a common mechanism by which cellular asymmetry is achieved. In higher eukaryotes the mRNA transport machinery is required for such diverse processes as stem cell division and neuronal plasticity. Because mRNA localization in metazoans is highly complex, studies at the molecular level have proven to be cumbersome. However, active mRNA transport has also been reported in fungi including Saccharomyces cerevisiae, Ustilago maydis and Candida albicans, in which these events are less difficult to study. Amongst them, budding yeast S. cerevisiae has yielded mechanistic insights that exceed our understanding of other mRNA localization events to date. In contrast to most reviews, we refrain here from summarizing mRNA localization events from different organisms. Instead we give an in-depth account of ASH1 mRNA localization in budding yeast. This approach is particularly suited to providing a more holistic view of the interconnection between the individual steps of mRNA localization, from transcriptional events to cytoplasmic mRNA transport and localized translation. Because of our advanced mechanistic understanding of mRNA localization in yeast, the present review may also be informative for scientists working, for example, on mRNA localization in embryogenesis or in neurons.
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Publication type
Article: Journal article
Document type
Review
Keywords
mRNA localization; She2p; She3p; ASH1 mRNA; Translational control; Myosin; CLASS-V MYOSIN; SINGLE-STRANDED RNA; SACCHAROMYCES-CEREVISIAE; BINDING PROTEIN; BUDDING YEAST; RIBONUCLEOPROTEIN COMPLEXES; TRANSLATIONAL CONTROL; INTRACELLULAR-LOCALIZATION; CYTOPLASMIC LOCALIZATION; ASYMMETRIC LOCALIZATION
ISSN (print) / ISBN
1420-682X
e-ISSN
1420-9071
Quellenangaben
Volume: 69,
Issue: 11,
Pages: 1843-1853
Publisher
Birkhäuser
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Structural Biology (STB)