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Fibrogenic pathways in metabolic dysfunction associated fatty liver disease (MAFLD).
Int. J. Mol. Sci. 23:6996 (2022)
The prevalence of nonalcoholic fatty liver disease (NAFLD), recently also re-defined as metabolic dysfunction associated fatty liver disease (MAFLD), is rapidly increasing, affecting ~25% of the world population. MALFD/NAFLD represents a spectrum of liver pathologies including the more benign hepatic steatosis and the more advanced non-alcoholic steatohepatitis (NASH). NASH is associated with enhanced risk for liver fibrosis and progression to cirrhosis and hepatocellular carcinoma. Hepatic stellate cells (HSC) activation underlies NASH-related fibrosis. Here, we discuss the profibrogenic pathways, which lead to HSC activation and fibrogenesis, with a particular focus on the intercellular hepatocyte-HSC and macrophage-HSC crosstalk.
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Publication type
Article: Journal article
Document type
Review
Keywords
Fibrosis ; Hepatic Stellate Cells ; Hepatocyte ; Macrophage ; Metabolic Associated Fatty Liver Disease ; Nonalcoholic Fatty Liver Disease ; Nonalcoholic Steatohepatitis
ISSN (print) / ISBN
1422-0067
e-ISSN
1661-6596
Quellenangaben
Volume: 23,
Issue: 13,
Article Number: 6996
Publisher
MDPI
Publishing Place
Basel
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Pancreatic Islet Research (IPI)
Grants
Federal Ministry of Education and Research