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Sahu, T.* ; Pande, B.* ; Sinha, M.* ; Sinha, R.* ; Verma, H.K.

Neurocognitive changes in sickle cell disease: A comprehensive review.

Ann. Neurosci. 29, 255-268 (2022)
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Background: Sickle cell disease (SCD) is a type of hemoglobinopathy characterized by abnormal hemoglobin molecules, which includes numerous acute and chronic complications. Ischemic stroke, silent cerebral infarction, headache, and neurocognitive impairment are the most common neurological complications associated with SCD. Summary: Acute anemia because of SCD can cause cognitive impairments because of cerebral hypoxia. Cognitive abnormalities in SCD manifest in various aspects such as working memory, verbal learning, executive functions, and attention. These neurocognitive impairments have been associated with poor functional results, such as transitioning from juvenile to adult care, adherence to medications, and unemployment. Key message: In this review, we focus on neurocognitive aspects of SCD patients based on different imaging techniques, psychological batteries, associated neuromarkers, and interventions for managing of cognitive deficiencies.
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Publication type Article: Journal article
Document type Review
Keywords Cognition ; Neurocognition ; Neuroimaging ; Sickle Cell Disease; Transcranial Doppler Ultrasonography; Cerebral-blood-flow; Neuroimaging Abnormalities; Children; Anemia; Mri; Association; Adults; Dysfunction; Hemoglobin
Language english
Publication Year 2022
HGF-reported in Year 2022
ISSN (print) / ISBN 0972-7531
e-ISSN 0976-3260
Journal Annals of Neurosciences
Quellenangaben Volume: 29, Issue: 4, Pages: 255-268 Article Number: , Supplement: ,
Publisher Sage
Publishing Place 1 Olivers Yard, 55 City Road, London Ec1y 1sp, England
Reviewing status Peer reviewed
Institute(s) Institute of Lung Health and Immunity (LHI)
POF-Topic(s) 80000 - German Center for Lung Research
Research field(s) Lung Research
PSP Element(s) G-501810-007
DOI 10.1177/09727531221108871
WOS ID 000967559800010
Scopus ID 85133901441
PubMed ID 37064288
Erfassungsdatum 2022-07-21
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