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Byun, J.* ; Han, Y.* ; Li, Y.* ; Xia, J.* ; Long, E.* ; Choi, J.* ; Xiao, X.* ; Zhu, M.* ; Zhou, W.* ; Sun, R.* ; Bossé, Y.* ; Song, Z.* ; Schwartz, A.* ; Lusk, C.* ; Rafnar, T.* ; Stefansson, K.* ; Zhang, T.* ; Zhao, W.* ; Pettit, R.W.* ; Liu, Y.* ; Li, X.* ; Zhou, H.* ; Walsh, K.M.* ; Gorlov, I.* ; Gorlova, O.* ; Zhu, D.* ; Rosenberg, S.M.* ; Pinney, S.* ; Bailey-Wilson, J.E.* ; Mandal, D.* ; de Andrade, M.* ; Gaba, C.* ; Willey, J.C.* ; You, M.* ; Anderson, M.D.* ; Wiencke, J.K.* ; Albanes, D.* ; Lam, S.* ; Tardón, A.* ; Chen, C.* ; Goodman, G.* ; Bojeson, S.* ; Brenner, H.* ; Landi, M.T.* ; Chanock, S.J.* ; Johansson, M.* ; Muley, T.* ; Risch, A.* ; Wichmann, H.-E. ; Bickeböller, H.* ; Christiani, D.C.* ; Rennert, G.* ; Arnold, S.* ; Field, J.K.* ; Shete, S.* ; Le Marchand, L.* ; Melander, O.* ; Brunnström, H.* ; Liu, G.* ; Andrew, A.S.* ; Kiemeney, L.A.* ; Shen, H.* ; Zienolddiny, S.* ; Grankvist, K.* ; Caporaso, N.* ; Cox, A.* ; Hong, Y.C.* ; Yuan, J.M.* ; Lazarus, P.* ; Schabath, M.B.* ; Aldrich, M.C.* ; Patel, A.* ; Lan, Q.* ; Rothman, N.* ; Taylor, F.* ; Kachuri, L.* ; Witte, J.S.* ; Sakoda, L.C.* ; Spitz, M.* ; Brennan, P.* ; Lin, X.* ; Mckay, J.* ; Hung, R.J.* ; Amos, C.I.*

Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer.

Nat. Genet. 54, 1167-1177 (2022)
Postprint DOI PMC
Open Access Green
To identify new susceptibility loci to lung cancer among diverse populations, we performed cross-ancestry genome-wide association studies in European, East Asian and African populations and discovered five loci that have not been previously reported. We replicated 26 signals and identified 10 new lead associations from previously reported loci. Rare-variant associations tended to be specific to populations, but even common-variant associations influencing smoking behavior, such as those with CHRNA5 and CYP2A6, showed population specificity. Fine-mapping and expression quantitative trait locus colocalization nominated several candidate variants and susceptibility genes such as IRF4 and FUBP1. DNA damage assays of prioritized genes in lung fibroblasts indicated that a subset of these genes, including the pleiotropic gene IRF4, potentially exert effects by promoting endogenous DNA damage.
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Publication type Article: Journal article
Document type Scientific Article
Language english
Publication Year 2022
HGF-reported in Year 2022
ISSN (print) / ISBN 1061-4036
e-ISSN 1546-1718
Journal Nature Genetics
Quellenangaben Volume: 54, Issue: 8, Pages: 1167-1177 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place New York, NY
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
POF-Topic(s) 30202 - Environmental Health
Research field(s) Genetics and Epidemiology
PSP Element(s) G-504000-009
Grants NIA NIH HHS
Cancer Prevention and Research Institute of Texas (Cancer Prevention Research Institute of Texas)
U.S. Department of Health & Human Services | NIH | National Institute on Aging (U.S. National Institute on Aging)
NCRR NIH HHS

NIEHS NIH HHS
U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI)
U.S. Department of Health & Human Services | NIH | National Institute of Environmental Health Sciences (NIEHS)
NCI NIH HHS
NHLBI NIH HHS
DOI 10.1038/s41588-022-01115-x
WOS ID WOS:000834739900001
Scopus ID 85135272569
PubMed ID 35915169
Erfassungsdatum 2022-08-29
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