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Fiamoncini, J.* ; Rist, M.J.* ; Frommherz, L.* ; Giesbertz, P.* ; Pfrang, B.* ; Kremer, W.* ; Huber, F.* ; Kastenmüller, G. ; Skurk, T.* ; Hauner, H.* ; Suhre, K.* ; Daniel, H.* ; Kulling, S.E.*

Dynamics and determinants of human plasma bile acid profiles during dietary challenges.

Front. Nutr. 9:932937 (2022)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
In recent years, bile acids (BA) have received great interest due to their pleiotropic biological activity and the presence of plasma membrane-bound and nuclear receptors. Moreover, BA in blood have been identified by metabolite screening approaches as biomarkers that are associated with various diseases and even with a human longevity phenotype. With the growing interest in the microbiota contribution to the health-disease trajectory, BA that undergo deconjugation and other modifications by bacteria in the large intestine have become a prime target as a microbiome diversity modifier. We here profiled BA by a quantitative and a semiquantitative approach in 15 healthy and phenotypically very similar young individuals for over a 36-h fasting period, an oral glucose tolerance test (OGTT), and an oral lipid tolerance test (OLTT). We demonstrate a remarkable heterogeneity of the responses and describe the different dynamics of the plasma changes that likely originate from different routes by which BA enters the peripheral blood, and that may represent a direct secretion from the liver into the blood and a route that reaches the blood as a spill-over after passing from the gallbladder through the intestine and the portal system. We discuss the finding that an individual transport process involved in the passage of BA could be a critical determinant in the kinetics of plasma appearance and the overall phenotypic variability found.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Bile Salts ; Fasting ; Ogtt ; Oltt ; Postprandial
ISSN (print) / ISBN 2296-861X
e-ISSN 2296-861X
Journal Frontiers in Nutrition
Quellenangaben Volume: 9, Issue: , Pages: , Article Number: 932937 Supplement: ,
Publisher Frontiers
Publishing Place Lausanne
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Computational Biology (ICB)