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Bassler, K.* ; Fujii, W.* ; Kapellos, T.S.* ; Dudkin, E.* ; Reusch, N.* ; Horne, A.* ; Reiz, B.* ; Luecken, M. ; Osei-Sarpong, C.* ; Warnat-Herresthal, S.* ; Bonaguro, L.* ; Schulte-Schrepping, J.* ; Wagner, A.* ; Guenther, P.* ; Pizarro, C.* ; Schreiber, T.* ; Knöll, R.* ; Holsten, L.* ; Kroeger, C.* ; De Domenico, E.* ; Becker, M.* ; Haendler, K.* ; Wohnhaas, C.T.* ; Baumgartner, F.* ; Koehler, M.* ; Theis, H.* ; Kraut, M.* ; Wadsworth, M.H.* ; Hughes, T.K.* ; Ferreira, H.J.* ; Hinkley, E.* ; Kaltheuner, I.H.* ; Geyer, M.* ; Thiele, C.* ; Shalek, A.K.* ; Feisst, A.* ; Thomas, D.* ; Dickten, H.* ; Beyer, M.* ; Baum, P.* ; Yosef, N.* ; Aschenbrenner, A.C.* ; Ulas, T.* ; Hasenauer, J. ; Theis, F.J. ; Skowasch, D.* ; Schultze, J.L.*

Alveolar macrophages in early stage COPD show functional deviations with properties of impaired immune activation.

Front. Immunol. 13:917232 (2022)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Despite its high prevalence, the cellular and molecular mechanisms of chronic obstructive pulmonary disease (COPD) are far from being understood. Here, we determine disease-related changes in cellular and molecular compositions within the alveolar space and peripheral blood of a cohort of COPD patients and controls. Myeloid cells were the largest cellular compartment in the alveolar space with invading monocytes and proliferating macrophages elevated in COPD. Modeling cell-to-cell communication, signaling pathway usage, and transcription factor binding predicts TGF-β1 to be a major upstream regulator of transcriptional changes in alveolar macrophages of COPD patients. Functionally, macrophages in COPD showed reduced antigen presentation capacity, accumulation of cholesteryl ester, reduced cellular chemotaxis, and mitochondrial dysfunction, reminiscent of impaired immune activation.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Chronic Obstructive Pulmonary Disease ; Bronchoalveolar Lavage ; Blood ; Macrophage ; Monocyte ; Impaired Immune Activation ; Tgf-beta 1
ISSN (print) / ISBN 1664-3224
e-ISSN 1664-3224
Journal Frontiers in Immunology
Quellenangaben Volume: 13, Issue: , Pages: , Article Number: 917232 Supplement: ,
Publisher Frontiers
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Computational Biology (ICB)
Grants NIAID NIH HHS
NCI NIH HHS
NIMH NIH HHS