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Neumann, A.* ; Nolte, I.M.* ; Pappa, I.* ; Ahluwalia, T.S.* ; Pettersson, E.* ; Rodriguez, A.* ; Whitehouse, A.* ; van Beijsterveldt, C.E.M.* ; Benyamin, B.* ; Hammerschlag, A.R.* ; Helmer, Q.* ; Karhunen, V.* ; Krapohl, E.* ; Lu, Y.* ; van der Most, P.J.* ; Palviainen, T.* ; St Pourcain, B.* ; Seppälä, I.* ; Suarez, A.* ; Vilor-Tejedor, N.* ; Tiesler, C.M. ; Wang, C.* ; Wills, A.* ; Zhou, A.* ; Alemany, S.* ; Bisgaard, H.* ; Bønnelykke, K.* ; Davies, G.E.* ; Hakulinen, C.* ; Henders, A.K.* ; Hyppönen, E.* ; Stokholm, J.* ; Bartels, M.* ; Hottenga, J.J.* ; Heinrich, J.* ; Hewitt, J.K.* ; Keltikangas-Järvinen, L.* ; Korhonen, T.* ; Kaprio, J.* ; Lahti, J.* ; Lahti-Pulkkinen, M.* ; Lehtimäki, T.* ; Middeldorp, C.M.* ; Najman, J.M.* ; Pennell, C.E.* ; Power, C.* ; Oldehinkel, A.J.* ; Plomin, R.* ; Räikkönen, K.* ; Raitakari, O.T.* ; Rimfeld, K.* ; Sass, L.* ; Snieder, H.* ; Standl, M.* ; Sunyer, J.* ; Williams, G.M.* ; Bakermans-Kranenburg, M.J.* ; Boomsma, D.I.* ; van IJzendoorn, M.H.* ; Hartman, C.A.* ; Tiemeier, H.*

A genome-wide association study of total child psychiatric problems scores.

PLoS ONE 17:e0273116 (2022)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Substantial genetic correlations have been reported across psychiatric disorders and numerous cross-disorder genetic variants have been detected. To identify the genetic variants underlying general psychopathology in childhood, we performed a genome-wide association study using a total psychiatric problem score. We analyzed 6,844,199 common SNPs in 38,418 school-aged children from 20 population-based cohorts participating in the EAGLE consortium. The SNP heritability of total psychiatric problems was 5.4% (SE = 0.01) and two loci reached genome-wide significance: rs10767094 and rs202005905. We also observed an association of SBF2, a gene associated with neuroticism in previous GWAS, with total psychiatric problems. The genetic effects underlying the total score were shared with common psychiatric disorders only (attention-deficit/hyperactivity disorder, anxiety, depression, insomnia) (rG > 0.49), but not with autism or the less common adult disorders (schizophrenia, bipolar disorder, or eating disorders) (rG < 0.01). Importantly, the total psychiatric problem score also showed at least a moderate genetic correlation with intelligence, educational attainment, wellbeing, smoking, and body fat (rG > 0.29). The results suggest that many common genetic variants are associated with childhood psychiatric symptoms and related phenotypes in general instead of with specific symptoms. Further research is needed to establish causality and pleiotropic mechanisms between related traits.
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Publication type Article: Journal article
Document type Scientific Article
Language english
Publication Year 2022
HGF-reported in Year 2022
ISSN (print) / ISBN 1932-6203
Journal PLoS ONE
Quellenangaben Volume: 17, Issue: 8, Pages: , Article Number: e0273116 Supplement: ,
Publisher Public Library of Science (PLoS)
Publishing Place Lawrence, Kan.
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
POF-Topic(s) 30202 - Environmental Health
Research field(s) Genetics and Epidemiology
PSP Element(s) G-504000-008
Grants Nederlandse Organisatie voor Wetenschappelijk onderzoek
ZonMw
Horizon 2020 Framework Programme
NWO-VICI
Dutch Ministry of Education, Culture, and Science
DOI 10.1371/journal.pone.0273116
WOS ID WOS:000877093400037
Scopus ID 85136217109
PubMed ID 35994476
Erfassungsdatum 2022-09-02
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