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Seguchi, M.* ; Aytekin, A.* ; Lenz, T.* ; Nicol, P.* ; Klosterman, G.R.* ; Beele, A.* ; Sabic, E.* ; Utsch, L.* ; Alyaqoob, A.* ; Gorpas, D. ; Ntziachristos, V. ; Jaffer, F.A.* ; Rauschendorfer, P. ; Joner, M.*

Intravascular molecular imaging: Translating pathophysiology of atherosclerosis into human disease conditions.

Eur. Heart J. Cardiovasc. Imaging 24, e1-e16 (2022)
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Progression of atherosclerotic plaque in coronary arteries is characterized by complex cellular and non-cellular molecular interactions. Within recent years, atherosclerosis has been recognized as inflammation-driven disease condition, where progressive stages are characterized by morphological changes in plaque composition but also relevant molecular processes resulting in increased plaque vulnerability. While existing intravascular imaging modalities are able to resolve key morphological features during plaque progression, they lack capability to characterize the molecular profile of advanced atherosclerotic plaque. Because hybrid imaging modalities may provide incremental information related to plaque biology, they are expected to provide synergistic effects in detecting high risk patients and lesions. The aim of this article is to review existing literature on intravascular molecular imaging approaches, and to provide clinically oriented proposals of their application. In addition, we assembled an overview of future developments in this field geared towards detection of patients at risk for cardiovascular events.
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Publication type Article: Journal article
Document type Review
Corresponding Author
Keywords Coronary Artery ; Near-infrared Fluorescence ; Near-infrared Spectroscopy ; Photoacoustic ; Vulnerable Plaque
ISSN (print) / ISBN 2047-2404
e-ISSN 2047-2412
Journal European heart journal - cardiovascular imaging
Quellenangaben Volume: 24, Issue: 1, Pages: e1-e16 Article Number: , Supplement: ,
Publisher Oxford University Press
Publishing Place Oxford
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Biological and Medical Imaging (IBMI)
Grants LeDucq Foundation
German Center for Cardiovascular Research