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Current and future approaches for in vitro hit discovery in diabetes mellitus.
Drug Discov. Today 27:103331 (2022)
Publ. Version/Full Text
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DOI
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Type 2 diabetes mellitus (T2DM) is a serious public health problem. In this review, we discuss current and promising future drugs, targets, in vitro assays and emerging omics technologies in T2DM. Importantly, we open the perspective to image-based high-content screening (HCS), with the focus of combining it with metabolomics or lipidomics. HCS has become a strong technology in phenotypic screens because it allows comprehensive screening for the cell-modulatory activity of small molecules. Metabolomics and lipidomics screen for perturbations at the molecular level. The combination of these data-intensive comprehensive technologies is enabled by the rapid development of artificial intelligence. It promises a deep cellular and molecular phenotyping directly linked to chemical information about the applied drug candidates or complex mixtures.
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Publication type
Article: Journal article
Document type
Review
Keywords
Bioactives ; Cell Painting ; Drug Discovery ; Functional Metabolomics ; High-content Screening ; Lipidomics
ISSN (print) / ISBN
1359-6446
e-ISSN
1878-5832
Journal
Drug discovery today
Quellenangaben
Volume: 27,
Issue: 10,
Article Number: 103331
Publisher
Elsevier
Publishing Place
Cambridge
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Research Unit Analytical BioGeoChemistry (BGC)