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Obesity and cancer-extracellular matrix, angiogenesis, and adrenergic signaling as unusual suspects linking the two diseases.
Cancer Metastasis Rev. 41, 517–547 (2022)
Obesity is an established risk factor for several human cancers. Given the association between excess body weight and cancer, the increasing rates of obesity worldwide are worrisome. A variety of obesity-related factors has been implicated in cancer initiation, progression, and response to therapy. These factors include circulating nutritional factors, hormones, and cytokines, causing hyperinsulinemia, inflammation, and adipose tissue dysfunction. The impact of these conditions on cancer development and progression has been the focus of extensive literature. In this review, we concentrate on processes that can link obesity and cancer, and which provide a novel perspective: extracellular matrix remodeling, angiogenesis, and adrenergic signaling. We describe molecular mechanisms involved in these processes, which represent putative targets for intervention. Liver, pancreas, and breast cancers were chosen as exemplary disease models. In view of the expanding epidemic of obesity, a better understanding of the tumorigenic process in obese individuals might lead to more effective treatments and preventive measures.
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Publication type
Article: Journal article
Document type
Review
Keywords
Adrenergic Signaling ; Angiogenesis ; Cancer ; Fibrosis ; Obesity
ISSN (print) / ISBN
0167-7659
e-ISSN
1573-7233
Journal
Cancer and Metastasis Reviews
Quellenangaben
Volume: 41,
Pages: 517–547
Publishing Place
Dordrecht, Netherlands
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Diabetes and Cancer (IDC)
Grants
DFG
Helmholtz Future Topic Aging and Metabolic Programming
Helmholtz Association
Helmholtz Future Topic Aging and Metabolic Programming
Helmholtz Association