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Kilanowski, A. ; Thiering, E. ; Wang, G.* ; Kumar, A.* ; Kress, S.* ; Flexeder, C. ; Bauer, C.P.* ; Berdel, D.* ; von Berg, A.* ; Bergström, A.* ; Gappa, M.* ; Heinrich, J.* ; Herberth, G.* ; Koletzko, S.* ; Kull, I.* ; Melén, E.* ; Schikowski, T.* ; Peters, A. ; Standl, M.

Allergic disease trajectories up to adolescence: Characteristics, early-life and genetic determinants.

Allergy 78, 836-850 (2023)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
BACKGROUND: Allergic diseases often develop jointly during early childhood but differ in timing of onset, remission and progression. Their disease course over time is often difficult to predict and determinants are not well understood. OBJECTIVES: We aimed to identify trajectories of allergic diseases up to adolescence and to investigate their association with early-life and genetic determinants and clinical characteristics. METHODS: Longitudinal k-means clustering was used to derive trajectories of allergic diseases (asthma, atopic dermatitis and rhinitis) in two German birth cohorts (GINIplus/LISA). Associations with early-life determinants, polygenic risk scores, food and aeroallergen sensitization and lung function were estimated by multinomial models. Results were replicated in the independent Swedish BAMSE cohort. RESULTS: Seven allergic disease trajectories were identified: "Intermittently allergic", "rhinitis", "early-resolving dermatitis", "mid-persisting dermatitis", "multimorbid", "persisting dermatitis plus rhinitis" and "early-transient asthma". Family history of allergies was more prevalent in all allergic disease trajectories compared the non-allergic controls with stronger effect sizes for clusters comprising more than one allergic disease (e.g. RRR=5.0, 95%CI=[3.1-8.0] in the multimorbid versus 1.8[1.4-2.4] in the mild intermittently allergic cluster). Specific polygenic risk scores for single allergic diseases were significantly associated with their relevant trajectories. The derived trajectories and their association with genetic effects and clinical characteristics showed similar results in BAMSE. CONCLUSION: Seven robust allergic clusters were identified and showed associations with early life and genetic factors as well as clinical characteristics.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Allergic Diseases ; Epidemiology ; Longitudinal Clustering ; Polygenic Risk Score ; Trajectories; Atopic-dermatitis; Hay-fever; Asthma; Eczema; Childhood; Birth; Rhinitis; Risk; Persistence; Multimorbidity
ISSN (print) / ISBN 0105-4538
e-ISSN 1398-9995
Journal Allergy
Quellenangaben Volume: 78, Issue: 3, Pages: 836-850 Article Number: , Supplement: ,
Publisher Wiley
Publishing Place 111 River St, Hoboken 07030-5774, Nj Usa
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
Institute of Epidemiology II (EPI2)
Grants Commission of the European Communities, the 7th Framework Program
Federal Ministry for Environment (IUF Dusseldorf)
Fondation Nestle
H2020 European Research Council
Helmholtz Zentrum Munchen
Helmholtz-Zentrum fur Umweltforschung
Hjart-Lungfonden
Bundesministerium für Bildung und Forschung
Region Stockholm
Leibniz Research-Institute for Environmental Medicine at the University of Dusseldorf
Ludwig-Maximilians-Universitat Munchen
Marien-Hospital Wesel
Mead Johnson Nutrition
Pediatric Practice, Bad Honnef
Swedish Research Council
Technische Universitat Munchen
Karolinska Institutet SFO Epidemiology