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Trained immunity in type 2 immune responses.
Mucosal Immunol. 15, 1158-1169 (2022)
Immunological memory of innate immune cells, also termed "trained immunity", allows for cross-protection against distinct pathogens, but may also drive chronic inflammation. Recent studies have shown that memory responses associated with type 2 immunity do not solely rely on adaptive immune cells, such as T- and B cells, but also involve the innate immune system and epithelial cells. Memory responses have been described for monocytes, macrophages and airway epithelial cells of asthmatic patients as well as for macrophages and group 2 innate lymphoid cells (ILC2) from allergen-sensitized or helminth-infected mice. The metabolic and epigenetic mechanisms that mediate allergen- or helminth-induced reprogramming of innate immune cells are only beginning to be uncovered. Trained immunity has been implicated in helminth-driven immune regulation and allergen-specific immunotherapy, suggesting its exploitation in future therapies. Here, we discuss recent advances and key remaining questions regarding the mechanisms and functions of trained type 2 immunity in infection and inflammation.
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Publication type
Article: Journal article
Document type
Review
ISSN (print) / ISBN
1933-0219
e-ISSN
1933-0219
Journal
Mucosal Immunology
Quellenangaben
Volume: 15,
Issue: 6,
Pages: 1158-1169
Publisher
Nature Publishing Group
Publishing Place
UNITED STATES
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute for Allergy Research (IAF)
Grants
Helmholtz Initiative
Helmholtz
Helmholtz