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Open Access Green as soon as Postprint is submitted to ZB.
Nuclear receptors in energy metabolism.
Adv. Exp. Med. Biol. 1390, 61-82 (2022)
Nuclear receptors are master regulators of energy metabolism through the conversion of extracellular signals into gene expression signatures. The function of the respective nuclear receptor is tissue specific, signal and co-factor dependent. While normal nuclear receptor function is central to metabolic physiology, aberrant nuclear receptor signaling is linked to various metabolic diseases such as type 2 diabetes mellitus, obesity, or hepatic steatosis. Thus, the tissue specific manipulation of nuclear receptors is a major field in biomedical research and represents a treatment approach for metabolic syndrome. This chapter focuses on key nuclear receptors involved in regulating the metabolic function of liver, adipose tissue, skeletal muscle, and pancreatic β-cells. It also addresses the importance of nuclear co-factors for fine-tuning of nuclear receptor function. The mode of action, role in energy metabolism, and therapeutic potential of prominent nuclear receptors is outlined.
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Publication type
Article: Journal article
Document type
Review
Keywords
Energy Homeostasis ; Glucose And Lipid Metabolism ; Metabolic Syndrome ; Nuclear Receptor-based Therapies ; Transcriptional Co-factors; Growth-factor 21; Farnesoid-x-receptor; Improves Glucose-tolerance; Alpha Gene-expression; Ppar-gamma Activation; White Adipose-tissue; Lxr Inverse Agonist; Muscle-fiber-type; Glucocorticoid-receptor; Skeletal-muscle
ISSN (print) / ISBN
0065-2598
Quellenangaben
Volume: 1390,
Pages: 61-82
Publisher
Springer
Publishing Place
New York
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Diabetes and Cancer (IDC)
Grants
Else Kroner-Fresenius Foundation
Deutsche Forschungsgemeinschaft (DFG)
Helmholtz Future Topic Aging and Metabolic Programming (AMPro)
European Association for the Study of Diabetes (EASD)
Helmholtz Association - Initiative and Networking Fund
Deutsche Forschungsgemeinschaft (DFG)
Helmholtz Future Topic Aging and Metabolic Programming (AMPro)
European Association for the Study of Diabetes (EASD)
Helmholtz Association - Initiative and Networking Fund