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Breuninger, T.A.* ; Wawro, N. ; Freuer, D.* ; Reitmeier, S.* ; Artati, A. ; Grallert, H. ; Adamski, J. ; Meisinger, C.* ; Peters, A. ; Haller, D.* ; Linseisen, J.*

Fecal bile acids and neutral sterols are associated with latent microbial subgroups in the human gut.

Metabolites 12:846 (2022)

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Bile acids, neutral sterols, and the gut microbiome are intricately intertwined and each affects human health and metabolism. However, much is still unknown about this relationship. This analysis included 1280 participants of the KORA FF4 study. Fecal metabolites (primary and secondary bile acids, plant and animal sterols) were analyzed using a metabolomics approach. Dirichlet regression models were used to evaluate associations between the metabolites and twenty microbial subgroups that were previously identified using latent Dirichlet allocation. Significant associations were identified between 12 of 17 primary and secondary bile acids and several of the microbial subgroups. Three subgroups showed largely positive significant associations with bile acids, and six subgroups showed mostly inverse associations with fecal bile acids. We identified a trend where microbial subgroups that were previously associated with “healthy” factors were here inversely associated with fecal bile acid levels. Conversely, subgroups that were previously associated with “unhealthy” factors were positively associated with fecal bile acid levels. These results indicate that further research is necessary regarding bile acids and microbiota composition, particularly in relation to metabolic health.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords 16s Rrna Gene Sequencing ; Bile Acids ; Fecal Metabolites ; Gut Microbiota

ISSN (print) / ISBN 2218-1989

e-ISSN 2218-1989

Journal Metabolites

Quellenangaben Volume: 12, Issue: 9, Article Number: 846

Publisher MDPI

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Epidemiology II (EPI2)
CF Metabolomics & Proteomics (CF-MPC)
Institute of Experimental Genetics (IEG)

Grants Federal Ministry of Education and Research