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Liu, N. ; O'Connor, P. ; Gujrati, V. ; Anzenhofer,P. ; Klemm, U. ; Kleigrewe, K.* ; Sattler, M. ; Plettenburg, O. ; Ntziachristos, V.

Multifunctional croconaine nanoparticles for efficient optoacoustic imaging of deep tumors and photothermal therapy.

Nanophotonics 11, 4637–4647 (2022)
Publ. Version/Full Text Research data DOI
Open Access Gold
Creative Commons Lizenzvertrag
The proper design of near-infrared light-absorbing agents enables efficient optoacoustic imaging-guided phototherapy. In particular, several croconaine-based organic agents with excellent optical properties have been recently reported for this purpose. However, most of them absorb light below 800 nm, limiting deep-tissue imaging applications. To this end, we utilized a recently described novel croconaine derivative (CR880) to develop CR880-based nanoparticles (CR880-NPs) for effective in vivo delivery, deep tissue optoacoustic imaging and photothermal therapy applications. Radicals and strong π-πstacking in CR880 result in an 880 nm absorption peak with no blue-shift upon condensing to the solid phase. DSPE-PEG2000-formulated CR880-NPs exhibited high optoacoustic generation efficiency and photostability, and could be visualized in the tumors of three different mouse tumor models (breast, brain, and colon tumor) with high image contrast. The high photothermal conversion efficiency of CR880-NPs (∼58%) subsequently enabled efficient in vivo tumor elimination using a low energy laser, while remaining biocompatible and well-tolerated. This work introduces a promising novel agent for cancer theranostics of challenging deep-seated tumors.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords 880 Nm ; Croconaine ; Deep Tumors ; Nanoparticles ; Optoacoustics ; Photothermal Therapy
ISSN (print) / ISBN 2192-8606
e-ISSN 2192-8614
Journal Nanophotonics
Quellenangaben Volume: 11, Issue: 21, Pages: 4637–4647 Article Number: , Supplement: ,
Publisher Walter de Gruyter
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Biological and Medical Imaging (IBMI)
Institute of Medicinal Chemistry (IMC)
Institute of Structural Biology (STB)
Grants Helmholtz Association
China Scholarship Council
Bundesministerium für Bildung und Forschung
Deutsche Forschungsgemeinschaft
European Research Council
Horizon 2020 Framework Programme