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Gilleron, J.* ; Zeigerer, A.

Endosomal trafficking in metabolic homeostasis and diseases.

Nat. Rev. Endocrinol. 19, 28–45 (2023)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
The global prevalences of obesity and type 2 diabetes mellitus have reached epidemic status, presenting a heavy burden on society. It is therefore essential to find novel mechanisms and targets that could be utilized in potential treatment strategies and, as such, intracellular membrane trafficking has re-emerged as a regulatory tool for controlling metabolic homeostasis. Membrane trafficking is an essential physiological process that is responsible for the sorting and distribution of signalling receptors, membrane transporters and hormones or other ligands between different intracellular compartments and the plasma membrane. Dysregulation of intracellular transport is associated with many human diseases, including cancer, neurodegeneration, immune deficiencies and metabolic diseases, such as type 2 diabetes mellitus and its associated complications. This Review focuses on the latest advances on the role of endosomal membrane trafficking in metabolic physiology and pathology in vivo, highlighting the importance of this research field in targeting metabolic diseases.
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Publication type Article: Journal article
Document type Review
Corresponding Author
ISSN (print) / ISBN 1759-5029
e-ISSN 1759-5037
Journal Nature Reviews - Endocrinology
Quellenangaben Volume: 19, Issue: , Pages: 28–45 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place New York, NY
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Cancer (IDC)
Grants Université Côte d’Azur
Bundesministerium für Bildung und Forschung
Institut National de la Santé et de la Recherche Médicale
Deutsche Forschungsgemeinschaft
Institute for Diabetes and Cancer
Helmholtz Munich
German Institute for Human Nutrition Potsdam-Rehbruecke